Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | GBA2 | Q9HCG7 | 11/20 | 0.48 |
| ▸ | GBA1 | P04062 | 4/20 | 0.48 |
| ▸ | UGCG | Q16739 | 3/20 | 0.46 |
| ▸ | MGAM | O43451 | 2/20 | 0.46 |
| ▸ | SI | P14410 | 2/20 | 0.46 |
| ▸ | AGL | P35573 | 2/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Emiglitate SCHEMBL5188302 | 1.00 | KCNH2 (0.48) | KCNH2HRH3GAAGBA2GBA1 | |
| Emiglitate SCHEMBL5188305 | 1.00 | KCNH2 (0.48) | KCNH2HRH3GAAGBA2GBA1 | |
| Emiglitate SCHEMBL26909 | 1.00 | KCNH2 (0.48) | KCNH2HRH3GAAGBA2GBA1 | |
| SCHEMBL23996617 | 0.74 | GBA2 (0.60) | GAAGBA2GBA1UGCGMGAM | |
| SCHEMBL22048754 | 0.74 | KCNH2 (0.57) | KCNH2HRH3GAATBXAS1TDP1 | |
| SCHEMBL6701399 | 0.73 | TDP1 (0.74) | KCNH2HRH3TBXAS1TDP1L3MBTL1 | |
| SCHEMBL21408538 | 0.72 | HRH3 (0.79) | KCNH2HRH3L3MBTL1MEN1LMNA | |
| SCHEMBL6867384 | 0.72 | TDP1 (0.64) | KCNH2HRH3GAATBXAS1TDP1 | |
| SCHEMBL9199244 | 0.72 | KCNH2 (0.63) | KCNH2HRH3GAATBXAS1TDP1 | |
| SCHEMBL6999600 | 0.71 | MAPK1 (0.67) | KCNH2HRH3GAATBXAS1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007107843-A1 | METHODS OF TREATMENT WITH CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2007-09-27 | — | — | WO | disclosed |
| WO-2006033001-A1 | QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |