Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.63 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.63 |
| ▸ | MAOB | P27338 | 7/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446421 | 0.92 | ITGB3 (0.57) | ITGB3ITGA2BMAOBMAOA | |
| SCHEMBL5617917 | 0.88 | ITGB3 (0.66) | ITGB3ITGA2BMAOBMAOA | |
| SCHEMBL6450207 | 0.83 | MAOB (0.56) | ITGB3ITGA2BMAOBMAOASRD5A1 | |
| SCHEMBL3503559 | 0.81 | ITGB3 (0.57) | ITGB3ITGA2BMAOBMAOA | |
| SCHEMBL5617941 | 0.80 | MAOB (0.53) | ITGB3ITGA2BMAOBMAOASRD5A1 | |
| SCHEMBL4426050 | 0.78 | ITGB3 (0.69) | ITGB3ITGA2BMAOBMAOA | |
| SCHEMBL6470666 | 0.77 | ITGB3 (0.72) | ITGB3ITGA2BMAOBMAOA | |
| SCHEMBL3504992 | 0.77 | MAOB (0.56) | ITGB3ITGA2BMAOBMAOASRD5A1 | |
| SCHEMBL20233555 | 0.76 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL27543696 | 0.76 | MAOB (0.53) | ITGB3ITGA2BMAOBMAOASRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078172-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2007-04-05 | — | — | US | claimed |
| CN-1305848-C | 2,3-dihydro-isoindol-1-ones with MAO-B inhibiting activity | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | CN | claimed |
| CN-1675181-A | 2,3-dihydro-isoindol-1-ones with MAO-B inhibiting activity | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | claimed |
| US-20040082603-A1 | 2,3-Dihydro-isoindol-1-one derivatives | HOFFMANN-LA ROCHE INC. | 2004-04-29 | — | — | US | claimed |
| US-20070078172-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2007-04-05 | — | — | US | disclosed |
| CN-1305848-C | 2,3-dihydro-isoindol-1-ones with MAO-B inhibiting activity | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | CN | disclosed |
| CN-1675181-A | 2,3-dihydro-isoindol-1-ones with MAO-B inhibiting activity | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | CN | disclosed |
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6846832-B2 | 2,3-dihydro-isoindol-1-one derivatives | HOFFMAN-LA ROCHE INC. (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040082603-A1 | 2,3-Dihydro-isoindol-1-one derivatives | HOFFMANN-LA ROCHE INC. | 2004-04-29 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078172-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | MAOB, MAOA, GPR119 | ITGB3 3604/4885ITGA2B 2593/4885MAOB 1/4885 |
| US-20040082603-A1 | 2,3-Dihydro-isoindol-1-one derivatives | MAOB, MAOA, COMT | ITGB3 3485/4885ITGA2B 2584/4885MAOB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.