Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618494 | 0.87 | MAPK10 (0.62) | MAPK8MAPK9MAPK10MKNK2MKNK1 | |
| SCHEMBL5617651 | 0.86 | ALDH1A1 (0.45) | MKNK2MKNK1ALOX5APOGAFGFR1 | |
| SCHEMBL5618342 | 0.86 | HTT (0.37) | MAPK8MAPK9MAPK10MKNK2MKNK1 | |
| SCHEMBL5398186 | 0.84 | MAPK8 (0.48) | MAPK8MAPK9MAPK10MKNK2MKNK1 | |
| SCHEMBL5427414 | 0.82 | NPSR1 (0.36) | MKNK2MKNK1ALOX5APMEN1PKM | |
| SCHEMBL5618220 | 0.81 | MAPK8 (0.44) | MAPK8MAPK9MAPK10MKNK2MKNK1 | |
| SCHEMBL3562691 | 0.80 | MAPK10 (0.52) | MAPK8MAPK9MAPK10MKNK2MKNK1 | |
| SCHEMBL5617940 | 0.79 | MAPK10 (0.50) | MAPK8MAPK9MAPK10MKNK2MKNK1 | |
| SCHEMBL5617823 | 0.79 | SMN1; SMN2 (0.48) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL5618112 | 0.78 | NPSR1 (0.39) | MAPK8MAPK9MAPK10MKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203134-A1 | Benzimidazole Acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203134-A1 | Benzimidazole Acetonitriles | PKD1, GPR119, CCNI | MAPK8 2377/4885MAPK9 3702/4885MAPK10 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.