Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3891147 | 1.00 | TACR1 (0.47) | TACR1ACEPOLBCHEK1JAK2 | |
| SCHEMBL25349861 | 1.00 | TACR1 (0.47) | TACR1ACEPOLBCHEK1JAK2 | |
| SCHEMBL30167025 | 0.85 | PTPN1 (0.47) | TACR1ACEMEN1KMT2AF10 | |
| SCHEMBL3550883 | 0.85 | PTPN1 (0.47) | TACR1ACEMEN1KMT2AF10 | |
| SCHEMBL24172862 | 0.85 | PTPN1 (0.47) | TACR1ACEMEN1KMT2AF10 | |
| SCHEMBL30167036 | 0.85 | PTPN1 (0.47) | TACR1ACEMEN1KMT2AF10 | |
| SCHEMBL3550881 | 0.85 | PTPN1 (0.47) | TACR1ACEMEN1KMT2AF10 | |
| SCHEMBL25377304 | 0.81 | ACE (0.50) | TACR1ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL25377122 | 0.81 | ACE (0.52) | TACR1ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL25378995 | 0.80 | ACE (0.51) | TACR1ACEPOLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728938-B | Tetrahydroisoquinoline spiro compounds as PRMT5 inhibitors | 南京再明医药有限公司 | 2024-05-24 | — | — | CN | disclosed |
| US-20230250108-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND USE THEREOF | NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) | 2023-08-10 | — | — | US | disclosed |
| EP-4174064-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND USE THEREOF | Jiangsu Simcere Pharmaceutical Co., Ltd. (CN) | 2023-05-03 | — | — | EP | disclosed |
| CN-114728938-A | Tetrahydroisoquinoline spiro compounds as PRMT5 inhibitors | 江苏先声药业有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-1675859-B1 | MODULATORS OF SEROTONIN RECEPTORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-05 | — | — | EP | disclosed |
| US-7244843-B2 | Modulators of serotonin receptors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| EP-1675859-A1 | MODULATORS OF SEROTONIN RECEPTORS | Bristol-Myers Squibb Company (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005035533-A1 | MODULATORS OF SEROTONIN RECEPTORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-21 | — | — | WO | disclosed |
| US-20050080074-A1 | Modulators of serotonin receptors | BRISTOL-MYERS SQUIBB COMPANY | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230250108-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND USE THEREOF | PRMT5, PRMT1, PRMT3 | TACR1 4764/4885ACE 2318/4885POLB 3336/4885 |
| US-20050080074-A1 | Modulators of serotonin receptors | HTR5A, HTR1A, HTR2B | TACR1 49/4885ACE 3230/4885POLB 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.