Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618420 | 0.76 | FLT3 (0.46) | TBXAS1PIN1MMP13SMAD3GRIA1 | |
| SCHEMBL15642601 | 0.69 | MMP2 (0.68) | PIN1MMP13MMP2MMP14IDO1 | |
| SCHEMBL1550144 | 0.68 | MMP2 (0.65) | TBXAS1PIN1MMP13MMP2MMP14 | |
| SCHEMBL15653618 | 0.65 | PIN1 (0.63) | TBXAS1PIN1MMP13MMP2SMAD3 | |
| SCHEMBL168527 | 0.65 | DAO (0.58) | TBXAS1PIN1SMAD3F7F3 | |
| SCHEMBL3640951 | 0.64 | PIN1 (0.54) | PIN1MMP13MMP2MMP14SMAD3 | |
| SCHEMBL22777743 | 0.64 | KDM4E (0.66) | PIN1IDO1SMAD3F7F3 | |
| SCHEMBL3700465 | 0.64 | KDM4E (0.66) | PIN1IDO1SMAD3F7F3 | |
| SCHEMBL6478522 | 0.63 | SMAD3 (0.60) | PIN1SMAD3F7F3KDM4E | |
| SCHEMBL1895337 | 0.62 | DAO (0.58) | TBXAS1PIN1IDO1SMAD3F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | claimed |