Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.57 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895337 | 0.86 | DAO (0.58) | DAOKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL29414290 | 0.86 | DAO (0.58) | DAOKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL12647210 | 0.84 | HRH4 (0.59) | DAOHRH4CNR2NAMPTCYP2C9 | |
| SCHEMBL157702 | 0.84 | HRH4 (0.56) | DAOHRH4CNR2NAMPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL29228902 | 0.84 | DAO (0.56) | DAOKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL24112867 | 0.80 | CNR2 (0.59) | DAOHRH4CNR2NAMPTCYP2C9 | |
| SCHEMBL29263824 | 0.80 | KDM4E (0.62) | KDM4EHRH4CNR2ALDH1A1NAMPT | |
| SCHEMBL14666019 | 0.80 | HRH4 (0.56) | DAOHRH4CNR2NAMPTCYP2C9 | |
| SCHEMBL28610769 | 0.80 | HRH4 (0.56) | DAOMAPTHRH4CNR2NAMPT | |
| SCHEMBL1569349 | 0.80 | NAMPT (0.64) | DAOHRH4CNR2NAMPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103384668-B | compounds and compositions for inhibition of NAMPT | 福马TM有限责任公司 | 2017-05-31 | — | — | CN | claimed |
| EP-2820017-B1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | GENENTECH INC (US) | 2016-12-21 | — | — | EP | claimed |
| US-20160355514-A1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | VALO EARLY DISCOVERY, INC. | 2016-12-08 | — | — | US | claimed |
| US-9458172-B2 | Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives | VALO HEALTH, INC. | 2016-10-04 | — | — | US | claimed |
| US-20150175621-A1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | Valo Health, LLC | 2015-06-25 | — | — | US | claimed |
| CN-104507936-A | Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives | FORMA TM LLC | 2015-04-08 | — | — | CN | claimed |
| EP-2731439-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2014-05-21 | — | — | EP | claimed |
| CN-103384668-A | Novel compounds and compositions for inhibiting NAMPT | FORMA THERAPEUTICS INC | 2013-11-06 | — | — | CN | claimed |
| WO-2013009582-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2013-01-17 | — | — | WO | claimed |
| EP-1636224-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE | PROSIDION LTD (GB) | 2010-07-14 | — | — | EP | claimed |
| CN-100480249-C | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2009-04-22 | — | — | CN | claimed |
| US-20090023703-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PROSIDION LIMITED (GB) | 2009-01-22 | — | — | US | claimed |
| US-20070244090-A9 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSPHORYLASE | BRADLEY STUART E | 2007-10-18 | — | — | US | claimed |
| CN-1826340-A | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2006-08-30 | — | — | CN | claimed |
| US-20050261272-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PROSIDION LIMITED (GB) | 2005-11-24 | — | — | US | claimed |
| US-20260116857-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS | PARDES BIOSCIENCES INC (US) | 2026-04-30 | — | — | US | disclosed |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| US-5360799-A | Free radical inhibitors | ELF SANOFI (FR) | 1994-11-01 | — | — | US | disclosed |
| EP-0507861-A1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS. | UPJOHN CO (US) | 1992-10-14 | — | — | EP | disclosed |
| WO-1991009849-A1 | DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260116857-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS | CTRC, CTRL, CTSL | DAO 459/4885KDM4E 2746/4885HPGD 3164/4885 |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NNT | DAO 1925/4885KDM4E 1401/4885HPGD 188/4885 |
| US-20070244090-A9 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSPHORYLASE | PYGL, PYGM, PYGB | DAO 768/4885KDM4E 2422/4885HPGD 306/4885 |
| US-20090023703-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PYGL, PYGM, PYGB | DAO 768/4885KDM4E 2422/4885HPGD 306/4885 |
| US-20160355514-A1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | TPMT, TYMS, TYMP | DAO 2286/4885KDM4E 2902/4885HPGD 381/4885 |
| US-20050261272-A1 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase | PYGL, PYGM, PYGB | DAO 768/4885KDM4E 2422/4885HPGD 306/4885 |
| US-20150175621-A1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | TPMT, TYMS, TYMP | DAO 2286/4885KDM4E 2902/4885HPGD 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.