Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | RORC | P51449 | 6/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 10/20 | 0.57 |
| ▸ | RORA | P35398 | 3/20 | 0.57 |
| ▸ | RORB | Q92753 | 3/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.57 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622256 | 0.85 | ESR1 (0.68) | KEAP1NFE2L2RORCNR1H2ALDH1A1 | |
| SCHEMBL28467162 | 0.83 | ESR1 (0.46) | KEAP1NFE2L2RORCNR1I2RORA | |
| SCHEMBL5622498 | 0.81 | KEAP1 (0.68) | KEAP1NFE2L2ALDH1A1LMNANR3C1 | |
| SCHEMBL5623558 | 0.80 | ESR1 (0.72) | RORCNR1I2RORARORBNR1H4 | |
| SCHEMBL28426841 | 0.79 | APLNR (0.51) | KEAP1NFE2L2RORCNR1I2RORA | |
| SCHEMBL6962920 | 0.78 | NR3C1 (0.68) | KEAP1NFE2L2ALDH1A1LMNANR3C1 | |
| SCHEMBL5622632 | 0.78 | KEAP1 (0.64) | KEAP1NFE2L2ALDH1A1LMNANR3C1 | |
| SCHEMBL5623334 | 0.77 | KEAP1 (0.62) | KEAP1NFE2L2RORCNR1H2ALDH1A1 | |
| SCHEMBL1631020 | 0.76 | KEAP1 (0.87) | KEAP1NFE2L2 | |
| SCHEMBL1630208 | 0.76 | KEAP1 (0.81) | KEAP1NFE2L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021495-A1 | SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021495-A1 | SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR | ESR1, ESR2, GPER1 | KEAP1 2322/4885NFE2L2 791/4885RORC 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.