Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497453 | 0.94 | THRB (0.45) | THRBMAP2K2MAP2K1MAPK1HTT | |
| SCHEMBL5624190 | 0.91 | MAP2K2 (0.50) | THRBMAP2K2MAP2K1MAPK1TP53 | |
| SCHEMBL5624185 | 0.90 | MAP2K2 (0.47) | THRBMAP2K2MAP2K1MAPK1HTT | |
| SCHEMBL5622895 | 0.89 | MAP2K1 (0.61) | MAP2K2MAP2K1SYK | |
| SCHEMBL5623989 | 0.89 | MAP2K1 (0.49) | THRBMAP2K2MAP2K1MAPK1TP53 | |
| SCHEMBL6504254 | 0.86 | MAP2K2 (0.44) | THRBMAP2K2MAP2K1TP53MAPT | |
| SCHEMBL6499106 | 0.85 | MAP2K2 (0.46) | MAP2K2MAP2K1MAPK1LMNATP53 | |
| SCHEMBL6505710 | 0.85 | MAP2K1 (0.57) | MAP2K2MAP2K1TP53JAK2JAK1 | |
| SCHEMBL5623815 | 0.84 | MAP2K2 (0.42) | THRBMAP2K2MAP2K1TP53MAPT | |
| SCHEMBL6505308 | 0.84 | MAP2K1 (0.47) | THRBMAP2K2MAP2K1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273877-B2 | 5-substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives | WARNER-LAMBERT COMPANY, LLC (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273877-B2 | 5-substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives | WARNER-LAMBERT COMPANY, LLC (US) | 2007-09-25 | — | — | US | disclosed |
| US-7273877-B2 | 5-substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives | WARNER-LAMBERT COMPANY, LLC (US) | 2007-09-25 | — | — | US | disclosed |
| US-20050026964-A1 | 5-Substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives | WARNER-LAMBERT COMPANY LLC | 2005-02-03 | — | — | US | disclosed |
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026964-A1 | 5-Substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives | CYP3A5, CYP4B1, CYP3A4 | THRB 3088/4885MAP2K2 3777/4885MAP2K1 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.