Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5623906 | 0.94 | THRB (0.49) | THRBMAP2K2MAP2K1CSF1RMAPK1 | |
| SCHEMBL6499106 | 0.92 | MAP2K2 (0.46) | MAP2K2MAP2K1CSF1RMAPK1LMNA | |
| SCHEMBL6505308 | 0.90 | MAP2K1 (0.47) | THRBMAP2K2MAP2K1MAPK1JAK2 | |
| SCHEMBL5624190 | 0.85 | MAP2K2 (0.50) | THRBMAP2K2MAP2K1CSF1RMAPK1 | |
| SCHEMBL5624185 | 0.84 | MAP2K2 (0.47) | THRBMAP2K2MAP2K1MAPK1HTT | |
| SCHEMBL5623989 | 0.83 | MAP2K1 (0.49) | THRBMAP2K2MAP2K1MAPK1TP53 | |
| SCHEMBL5622895 | 0.83 | MAP2K1 (0.61) | MAP2K2MAP2K1 | |
| SCHEMBL6504254 | 0.81 | MAP2K2 (0.44) | THRBMAP2K2MAP2K1JAK2JAK1 | |
| SCHEMBL6505710 | 0.80 | MAP2K1 (0.57) | MAP2K2MAP2K1JAK2JAK1TYK2 | |
| SCHEMBL5623815 | 0.78 | MAP2K2 (0.42) | THRBMAP2K2MAP2K1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |