Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622895 | 0.96 | MAP2K1 (0.61) | MAP2K1MAP2K2SYK | |
| SCHEMBL6504254 | 0.89 | MAP2K2 (0.44) | MAP2K1MAP2K2TP53SYKJAK2 | |
| SCHEMBL6529013 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2 | |
| SCHEMBL5624190 | 0.85 | MAP2K2 (0.50) | MAP2K1MAP2K2TP53SYKJAK2 | |
| SCHEMBL5623906 | 0.85 | THRB (0.49) | MAP2K1MAP2K2TP53SYKJAK2 | |
| SCHEMBL3873690 | 0.85 | TP53 (0.49) | MAP2K1MAP2K2TP53SYKJAK2 | |
| SCHEMBL5624185 | 0.84 | MAP2K2 (0.47) | MAP2K1MAP2K2TP53SYKJAK2 | |
| SCHEMBL5623989 | 0.83 | MAP2K1 (0.49) | MAP2K1MAP2K2TP53SYK | |
| SCHEMBL6317553 | 0.83 | MAP2K1 (0.61) | MAP2K1MAP2K2SYK | |
| SCHEMBL6497453 | 0.80 | THRB (0.45) | MAP2K1MAP2K2TP53JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |