SCHEMBL5625518

SCHEMBL5625518

O=C(c1ccc2c(c1)OCO2)N1CC=CCC1

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 7/20 0.67
ALDH1A1 P00352 7/20 0.67
HSD17B10 Q99714 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
CYP2D6 P10635 1/20 0.65
CYP2C9 P11712 1/20 0.65
CYP2C19 P33261 1/20 0.65
GAA P10253 1/20 0.60
TSHR P16473 3/20 0.56
GFER P55789 1/20 0.56
NPC1 O15118 1/20 0.55
TP53 P04637 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
LMNA P02545 1/20 0.54
KMT2A Q03164 1/20 0.54
RECQL P46063 1/20 0.54
POLB P06746 1/20 0.53
MAPK1 P28482 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7169517 0.91 HPGD (0.65) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL13486222 0.90 HPGD (0.71) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL108225 0.83 ALDH1A1 (0.90) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL5970063 0.80 HPGD (1.00) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL244547 0.79 HPGD (1.00) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL13486221 0.79 HPGD (1.00) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL14140751 0.79 HPGD (1.00) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL22226790 0.77 HPGD (0.44) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL7464300 0.77 HPGD (0.75) HPGDALDH1A1HSD17B10CYP1A2CYP3A4
SCHEMBL7433458 0.77 HPGD (0.75) HPGDALDH1A1HSD17B10CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006034196-A1 COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR LIFELIKE BIOMATIC INC. (US) 2006-03-30 WO claimed
US-20060063707-A1 Compositions for enhancing memory and methods therefor LIFELIKE BIOMATIC, INC. (US) 2006-03-23 US claimed
US-20170209425-A1 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING UNIV CASE WESTERN RESERVE (US) 2017-07-27 US disclosed
US-20170209425-A1 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING UNIV CASE WESTERN RESERVE (US) 2017-07-27 US disclosed
US-20100144868-A1 Novel Neuroprotective Compounds and Uses Thereof RAMOT AT AVIV UNIVERSITY LTD. (IL) 2010-06-10 US disclosed
US-20100144868-A1 Novel Neuroprotective Compounds and Uses Thereof RAMOT AT AVIV UNIVERSITY LTD. (IL) 2010-06-10 US disclosed
US-20100035877-A1 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR NIH 2010-02-11 US disclosed
US-20100035877-A1 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR NIH 2010-02-11 US disclosed
US-20080176793-A1 UPREGULATING ACTIVITY OR EXPRESSION OF BDNF TO MITIGATE COGNITIVE IMPAIRMENT IN ASYMPTOMATIC HUNTINGTON'S SUBJECTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-07-24 US disclosed
US-7235548-B2 Compounds and their use as positive AMPA receptor modulators NEUROSEARCH A/S (DK) 2007-06-26 US disclosed
WO-2006034196-A1 COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR LIFELIKE BIOMATIC INC. (US) 2006-03-30 WO disclosed
EP-1156043-A2 Drugs that enhance synaptic responses mediated by ampa receptors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-11-21 EP disclosed
US-6274600-B1 COGNITION ACTIVATORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-08-14 US disclosed
EP-1071426-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 2001-01-31 EP disclosed
WO-1999042456-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 1999-08-26 WO disclosed
US-5891876-A ALPHA-AMINO-3-HYDROXY-5-METHYL-ISOXAZOLE-4-PROPIONIC ACID (AMPA); DRUGS THAT ENHANCE THESE RECEPTOR CURRENTS WILL FACILITATE COMMUNICATION IN BRAIN NETWORKS RESPONSIBLE FOR PERCEPTUAL-MOTOR INTEGRATION AND HIGHER ORDER BEHAVIORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-04-06 US disclosed
US-5852008-A Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-12-22 US disclosed
US-5747492-A IMPROVING MEMORY; A-AMINO-3-HYDROXY-5-METHYL ISOOXAZOLE-4-PROPIONIC ACID THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-05-05 US disclosed
EP-0651746-A1 DRUGS THAT ENHANCE SYNAPTIC RESPONSES MEDIATED BY AMPA RECEPTORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-05-10 EP disclosed
WO-1994002475-A1 DRUGS THAT ENHANCE SYNAPTIC RESPONSES MEDIATED BY AMPA RECEPTORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060063707-A1 Compositions for enhancing memory and methods therefor GRIN1, GRIN3A, GRIN2A HPGD 1202/4885ALDH1A1 4321/4885HSD17B10 4362/4885
US-20080176793-A1 UPREGULATING ACTIVITY OR EXPRESSION OF BDNF TO MITIGATE COGNITIVE IMPAIRMENT IN ASYMPTOMATIC HUNTINGTON'S SUBJECTS BDNF, HTT, NTRK2 HPGD 2638/4885ALDH1A1 4137/4885HSD17B10 1322/4885
US-20170209425-A1 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING NTRK2, BDNF, NGF HPGD 3434/4885ALDH1A1 2314/4885HSD17B10 4122/4885
US-20100144868-A1 Novel Neuroprotective Compounds and Uses Thereof GRM2, GRIN1, GRM3 HPGD 2407/4885ALDH1A1 1291/4885HSD17B10 2226/4885
US-20100035877-A1 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING NTRK2, NGF, BDNF HPGD 2739/4885ALDH1A1 2307/4885HSD17B10 3395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.