Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL15577173 | 0.93 | CYP1A2 (0.43) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| D-Glutamate SCHEMBL8218829 | 0.88 | BBOX1 (0.43) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| D-Glutamate SCHEMBL15577133 | 0.88 | BBOX1 (0.43) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Glutamic Acid SCHEMBL15577174 | 0.86 | CYP1A2 (0.51) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| Glutamic Acid SCHEMBL10623303 | 0.86 | GRM8 (0.64) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| D-Glutamate SCHEMBL10623300 | 0.86 | GRM8 (0.64) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| D-Glutamate SCHEMBL28219176 | 0.85 | GRM8 (0.62) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| Aspartic Acid SCHEMBL6033509 | 0.83 | LMNA (0.41) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| D-Glutamate SCHEMBL2208071 | 0.83 | TSHR (0.50) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| Choline SCHEMBL1683103 | 0.80 | LMNA (0.46) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059446-A1 | MULTIVALENT IONIC LIQUIDS AS PROCESS AIDS FOR BITUMEN EXTRACTION | STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) | 2025-02-20 | — | — | US | claimed |
| US-11976311-B2 | Method of adjusting the pH of a pretreatment solution using carbon dioxide useful for integrating saccharification and fermentation of a biomass | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) | 2024-05-07 | — | — | US | claimed |
| CN-117343967-A | Direct current is utilized in separationCoupling multienzyme system strengthening CO in sub-liquid 2 Reduction method and application | 河南工业大学 | 2024-01-05 | — | — | CN | claimed |
| CN-116656753-A | Efficient and continuous phospholipid type arachidonic acid enzymatic method | 江南大学 | 2023-08-29 | — | — | CN | claimed |
| CN-114044852-B | Polymerizable eutectic solvent, conductive elastomer and preparation method of conductive elastomer | 江南大学 | 2022-11-22 | — | — | CN | claimed |
| CN-114044852-A | Polymerizable eutectic solvent, conductive elastomer and preparation method thereof | 江南大学 | 2022-02-15 | — | — | CN | claimed |
| US-20210214757-A1 | Method of adjusting the pH of a pretreatment solution using carbon dioxide useful for integrating saccharification and fermentation of a biomass | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC | 2021-07-15 | — | — | US | claimed |
| CN-109627122-A | A kind of biogas residue farmland compound fertilizer and preparation method thereof | 山东省农业科学院作物研究所 | 2019-04-16 | — | — | CN | claimed |
| WO-2016105538-A1 | ADJUSTING THE PH OF A PRETREATMENT SOLUTION USING CARBON DIOXIDE USEFUL FOR INTEGRATING SACCHARIFICATION AND FERMENTATION | SANDIA CORPORATION SANDIA NATIONAL LABORATORIES (US) | 2016-06-30 | — | — | WO | claimed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | claimed |
| US-20250059446-A1 | MULTIVALENT IONIC LIQUIDS AS PROCESS AIDS FOR BITUMEN EXTRACTION | STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) | 2025-02-20 | — | — | US | disclosed |
| CN-114621984-B | Method for synthesizing 1, 5-pentanediamine by using ionic liquid to strengthen lysine decarboxylase | 中国科学院过程工程研究所 | 2025-01-28 | — | — | CN | disclosed |
| US-20240226045-A9 | RUMEN-PROTECTED COMPOSITIONS AND METHODS OF MAKING THE SAME | BALCHEM CORPORATION | 2024-07-11 | — | — | US | disclosed |
| US-11976311-B2 | Method of adjusting the pH of a pretreatment solution using carbon dioxide useful for integrating saccharification and fermentation of a biomass | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) | 2024-05-07 | — | — | US | disclosed |
| WO-2024092005-A2 | RUMEN-PROTECTED COMPOSITIONS AND METHODS OF MAKING THE SAME | BALCHEM CORPORATION (US) | 2024-05-02 | — | — | WO | disclosed |
| WO-2016070125-A1 | SWITCHABLE IONIC LIQUIDS FOR BIOMASS PRETREATMENT AND ENZYMATIC HYDROLYSIS | SANDIA CORPORATION (US) | 2016-05-06 | — | — | WO | disclosed |
| EP-2895071-A1 | ROD SHAPED IMPLANTABLE BIOSENSOR | Brains Online Holding B.V. (NL) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014041190-A1 | ROD SHAPED IMPLANTABLE BIOSENSOR | BRAINS ONLINE HOLDING B.V. (NL) | 2014-03-20 | — | — | WO | disclosed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | disclosed |
| US-5187093-A | Pure culture from which microorganisms which are stable, do not catabolize carnitine and grow with betaine are chosen | LONZA LTD. (CH) | 1993-02-16 | — | — | US | disclosed |