Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL562413 | 0.81 | MAPK13 (0.43) | NPC1ALDH1A1RAB9AMAPK14GAA | |
| SCHEMBL561997 | 0.72 | CDK5 (0.36) | DHODH | |
| SCHEMBL562125 | 0.69 | PNP (0.42) | PKMGAA | |
| SCHEMBL563259 | 0.68 | RAB9A (0.42) | NPC1ALDH1A1RAB9AMAPK14 | |
| SCHEMBL29362981 | 0.65 | MAPK14 (0.72) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL940921 | 0.65 | MAPK14 (0.72) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL563044 | 0.64 | ADORA3 (0.31) | — | |
| SCHEMBL7812295 | 0.64 | IDO1 (0.61) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL1622053 | 0.64 | NOS2 (0.47) | ALDH1A1L3MBTL1GAA | |
| SCHEMBL2419807 | 0.63 | SMN1; SMN2 (0.37) | ALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815846-B2 | Family of antichagasics derived from imidazo[4,5-C][1,2,6]thiadiazine 2,2-dioxide | UNIVERSIDAD DE LA REPUBLICA DE URUGUAY (UY) | 2014-08-26 | — | — | US | claimed |
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | UNIVERSIDAD DE LA REPUB'LICA URUGUAY (UY) | 2012-02-09 | — | — | US | claimed |
| EP-2392577-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2011-12-07 | — | — | EP | claimed |
| US-8815846-B2 | Family of antichagasics derived from imidazo[4,5-C][1,2,6]thiadiazine 2,2-dioxide | UNIVERSIDAD DE LA REPUBLICA DE URUGUAY (UY) | 2014-08-26 | — | — | US | disclosed |
| US-8815846-B2 | Family of antichagasics derived from imidazo[4,5-C][1,2,6]thiadiazine 2,2-dioxide | UNIVERSIDAD DE LA REPUBLICA DE URUGUAY (UY) | 2014-08-26 | — | — | US | disclosed |
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | UNIVERSIDAD DE LA REPUB'LICA URUGUAY (UY) | 2012-02-09 | — | — | US | disclosed |
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | UNIVERSIDAD DE LA REPUB'LICA URUGUAY (UY) | 2012-02-09 | — | — | US | disclosed |
| EP-2392577-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2011-12-07 | — | — | EP | disclosed |
| EP-2392577-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086481-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035160-A1 | NEW FAMILY OF ANTICHAGASICS DERIVED FROM IMIDAZO[4,5-C][1,2,6]THIADIAZINE 2,2-DIOXIDE | THOC2, TUBGCP2, TBC1D5 | NPC1 3469/4885ALDH1A1 1329/4885PKM 4164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.