Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | YWHAG | P61981 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3866106 | 0.95 | ALDH1A1 (0.60) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL30168124 | 0.81 | HSD17B10 (0.59) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL3866085 | 0.81 | HSD17B10 (0.59) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL5698156 | 0.79 | ALDH1A1 (0.59) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL4469707 | 0.78 | MAPT (0.47) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL76351 | 0.77 | KMT2A (0.58) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL5425961 | 0.76 | KMT2A (0.57) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL3866358 | 0.75 | ALDH1A1 (0.49) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL7031588 | 0.74 | ALDH1A1 (0.89) | MAPTALDH1A1KMT2AMEN1THRB | |
| SCHEMBL6156455 | 0.74 | ALDH1A1 (0.96) | MAPTALDH1A1KMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183277-B2 | Alpha-((aryl or heteroaryl)ureido or carbamoyloxy)-N-heteroaryl amides; blood-coagulation factor Xa and VIIa inhibitors; synergistic mixtures with other antitumor agents or anticoagulants | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-7183277-B2 | Alpha-((aryl or heteroaryl)ureido or carbamoyloxy)-N-heteroaryl amides; blood-coagulation factor Xa and VIIa inhibitors; synergistic mixtures with other antitumor agents or anticoagulants | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-7183277-B2 | Alpha-((aryl or heteroaryl)ureido or carbamoyloxy)-N-heteroaryl amides; blood-coagulation factor Xa and VIIa inhibitors; synergistic mixtures with other antitumor agents or anticoagulants | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-20050171154-A1 | Carboxylic acid amides | MERCK PATENT GMBH (DE) | 2005-08-04 | — | — | US | disclosed |
| EP-1499591-A1 | CARBOXYLIC ACID AMIDES | MERCK PATENT GmbH (DE) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093235-A1 | CARBOXYLIC ACID AMIDES | MERCK PATENT GMBH (DE) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171154-A1 | Carboxylic acid amides | F11, F12, F2 | MAPT 4346/4885ALDH1A1 378/4885KMT2A 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.