Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL27892632 | 1.00 | NOS1 (0.46) | — | |
| Guanidine SCHEMBL828820 | 0.88 | — | — | |
| Guanidine SCHEMBL165720 | 0.87 | NOS2 (0.42) | — | |
| Guanidine SCHEMBL29983942 | 0.87 | — | — | |
| Guanidine SCHEMBL5613752 | 0.87 | — | — | |
| Guanidine SCHEMBL11330173 | 0.87 | — | — | |
| Guanidine SCHEMBL2003 | 0.87 | — | — | |
| Guanidine SCHEMBL23294325 | 0.85 | NOS1 (0.38) | — | |
| Guanidine SCHEMBL28923883 | 0.82 | — | — | |
| Guanidine SCHEMBL3310493 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945209-B1 | BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS | US GOV AS REPRESENTED BY THE SECRETARY OF THE UNITED STATES ARMY AND THE U S ARMY MEDICAL RESEARCH (US) | 2018-05-30 | — | — | EP | claimed |
| US-8691859-B2 | Broad spectrum antibacterial compounds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2014-04-08 | — | — | US | claimed |
| US-20110086877-A1 | Small Molecule Inhibitors of Botulinum Neurotoxins | BAVARI SINA | 2011-04-14 | — | — | US | claimed |
| US-7825154-B2 | Small molecule inhibitors of botulinum neurotoxins | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2010-11-02 | — | — | US | claimed |
| EP-1945209-A2 | BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS | United States Government As Represented By The Secretary of The United States Army And The U.S. Army Medical Research & Materiel Command (US) | 2008-07-23 | — | — | EP | claimed |
| WO-2008041966-A2 | BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE UNITED STATES ARMY AND THE U.S. ARMY MEDICAL RESEARCH & MATERIEL COMMAND (US) | 2008-04-10 | — | — | WO | claimed |
| US-20070112048-A1 | Broad Spectrum Antibacterial Compounds | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2007-05-17 | — | — | US | claimed |
| US-20070112049-A1 | nonpeptidic inhibitors of Botulinum neurotoxin A metalloprotease activity, such as 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-5-carboximidamide, used for treating, inhibiting or preventing intoxication caused by bacteria | ARMY, UNITED STATES | 2007-05-17 | — | — | US | claimed |
| US-20200407236-A1 | COPPER-DOPED DOUBLE PEROVSKITES AND USES THEREOF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2020-12-31 | — | — | US | disclosed |
| EP-1945209-B1 | BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS | US GOV AS REPRESENTED BY THE SECRETARY OF THE UNITED STATES ARMY AND THE U S ARMY MEDICAL RESEARCH (US) | 2018-05-30 | — | — | EP | disclosed |
| US-8691859-B2 | Broad spectrum antibacterial compounds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2014-04-08 | — | — | US | disclosed |
| EP-2207801-B1 | METHODS OF INHIBITING VIRAL INFECTION | FUNCTIONAL GENETICS INC (US) | 2013-04-17 | — | — | EP | disclosed |
| US-8207209-B2 | Methods of inhibiting viral infection | FUNCTIONAL GENETICS, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20120035198-A1 | Antiviral Compounds and Methods of Using Thereof | AMAN MOHAMMAD JAVAD (US) | 2012-02-09 | — | — | US | disclosed |
| US-20090012107-A1 | Antiviral Compounds and Methods of Using Thereof | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2009-01-08 | — | — | US | disclosed |
| WO-2008089125-A2 | ANTIVIRAL COMPOUNDS AND METHODS OF USING THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, ON BEHALF OF THE U.S. ARMY RESEARCH INSTITUTE OF INFECTIOUS DISEASES (US) | 2008-07-24 | — | — | WO | disclosed |
| EP-1945209-A2 | BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS | United States Government As Represented By The Secretary of The United States Army And The U.S. Army Medical Research & Materiel Command (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2008041966-A2 | BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE UNITED STATES ARMY AND THE U.S. ARMY MEDICAL RESEARCH & MATERIEL COMMAND (US) | 2008-04-10 | — | — | WO | disclosed |
| US-20070112048-A1 | Broad Spectrum Antibacterial Compounds | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2007-05-17 | — | — | US | disclosed |
| US-20070112049-A1 | nonpeptidic inhibitors of Botulinum neurotoxin A metalloprotease activity, such as 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-5-carboximidamide, used for treating, inhibiting or preventing intoxication caused by bacteria | ARMY, UNITED STATES | 2007-05-17 | — | — | US | disclosed |