Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.76 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.76 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.76 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.76 |
| ▸ | SCD | O00767 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635378 | 0.86 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5633973 | 0.85 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5634358 | 0.85 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5634621 | 0.85 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5633679 | 0.84 | MAPK13 (0.87) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5634706 | 0.83 | RAB9A (0.57) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5635397 | 0.83 | MAPK13 (0.77) | MAPK13MAPK12MAPK11MAPK14CCNA2 | |
| SCHEMBL5634557 | 0.82 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5634447 | 0.82 | NPC1 (0.71) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL5634379 | 0.82 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253197-B2 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-20040038990-A1 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038990-A1 | Aminothiazole derivatives | FABP4, GPR119, ABAT | MAPK13 3018/4885MAPK12 2608/4885MAPK11 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.