Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029015 | 0.92 | CHRNA7 (0.41) | GPR52POLBALDH1A1KMT2ACHRNA7 | |
| SCHEMBL4026644 | 0.77 | ABCG2 (0.49) | GPR52ALDH1A1HTTMAPTLMNA | |
| SCHEMBL372771 | 0.73 | CHRNA7 (0.43) | POLBALDH1A1KMT2ACHRNA7MAPT | |
| SCHEMBL5635882 | 0.70 | GPR183 (0.42) | POLBKMT2ACHRNA7MAPTHPGD | |
| SCHEMBL14381384 | 0.70 | GPR183 (0.42) | POLBKMT2ACHRNA7MAPTHPGD | |
| SCHEMBL11528932 | 0.69 | GPR52 (0.61) | GPR52ALDH1A1HTTMAPTLMNA | |
| SCHEMBL11528927 | 0.69 | GPR52 (0.61) | GPR52ALDH1A1HTTMAPTLMNA | |
| SCHEMBL14808705 | 0.69 | ALDH1A1 (0.58) | ALDH1A1HTT | |
| SCHEMBL4033241 | 0.67 | CHRNA7 (0.58) | GPR52POLBALDH1A1KMT2ACHRNA7 | |
| SCHEMBL4032717 | 0.67 | GAA (0.48) | GPR52ALDH1A1KMT2AALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | claimed |
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
| EP-1699802-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061511-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | CHRNG, CHRNE, CHRNA1 | GPR52 141/4885POLB 4283/4885ALDH1A1 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.