SCHEMBL5637772

SCHEMBL5637772

CN(CCOS(C)(=O)=O)C(=O)c1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.51
NSD2 O96028 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
GAA P10253 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
LIMK2 P53671 1/20 0.45
CDK4 P11802 2/20 0.44
CCND1 P24385 2/20 0.44
NAMPT P43490 1/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
DRD2 P14416 1/20 0.41
HDAC4 P56524 1/20 0.39
HTR7 P34969 1/20 0.39
ALDH1A1 P00352 2/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5635131 0.85 MEN1 (0.46) LIMK2CDK4CCND1HDAC6HDAC1
SCHEMBL5638410 0.81 CES2 (0.41) NAMPTHDAC6
SCHEMBL5637425 0.77 TNFSF11 (0.49) GAAALDH1A1RAB9AHPGD
SCHEMBL6972956 0.76 CNR2 (0.40) GAAALDH1A1
SCHEMBL15218736 0.76 MCHR1 (0.56) MCHR1NSD2CYP1A2CYP3A4GAA
SCHEMBL28283417 0.76 MCHR1 (0.56) MCHR1NSD2CYP1A2CYP3A4GAA
SCHEMBL5656552 0.75 KDM4E (0.36) ALDH1A1
SCHEMBL23417262 0.75 ALDH1A1 (0.44) LIMK2CDK4CCND1NAMPTDRD2
SCHEMBL7485101 0.75 MCHR1 (0.49) MCHR1NSD2CYP1A2CYP3A4GAA
SCHEMBL19997023 0.73 HTR7 (0.54) MCHR1NSD2GAACYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39679-E1 Substituted heterocycle fused gamma-carbolines BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2007-06-05 US disclosed
EP-1192165-B1 SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-09-22 EP disclosed
US-6713471-B1 SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-03-30 US disclosed