Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5640778 | 0.86 | MAPK14 (0.50) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5639961 | 0.85 | ALOX5 (0.44) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5637541 | 0.84 | MAPK14 (0.61) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5638989 | 0.84 | MAPK14 (0.46) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5641118 | 0.83 | MAPK14 (0.58) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5639815 | 0.81 | MAPK14 (0.46) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5638921 | 0.77 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12TSHR | |
| SCHEMBL5639239 | 0.72 | MAPK14 (0.64) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5639957 | 0.70 | MAPK14 (0.56) | ALOX5MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5638985 | 0.70 | MAPK14 (0.55) | ALOX5MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |
| US-20040116416-A1 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2004-06-17 | — | — | US | disclosed |