Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | FLT1 | P17948 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | STK3 | Q13188 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734453 | 0.89 | LRRK2 (0.41) | PDGFRBKDRFLT1FGFR1RET | |
| SCHEMBL6722350 | 0.89 | KDR (0.51) | PDGFRBKDRFLT1FGFR1RET | |
| SCHEMBL5642412 | 0.89 | MEN1 (0.42) | PDGFRBKDRFLT1FGFR1RET | |
| SCHEMBL5520438 | 0.82 | PIM1 (0.39) | PDGFRBPIM1KDRFLT1FGFR1 | |
| SCHEMBL6727036 | 0.78 | KDR (0.53) | PDGFRBKDRFLT1FGFR1RET | |
| SCHEMBL5642726 | 0.73 | ALK (0.46) | PDGFRBKDRFLT1FGFR1RET | |
| SCHEMBL5641003 | 0.73 | LRRK2 (0.41) | PDGFRBKDRRETFLT3ZAP70 | |
| SCHEMBL2114212 | 0.72 | KDR (0.44) | PDGFRBKDRFGFR1FLT3KIT | |
| SCHEMBL2114496 | 0.72 | LRRK2 (0.42) | PDGFRBKDRFGFR1RETFLT3 | |
| SCHEMBL5639627 | 0.72 | MEN1 (0.42) | PDGFRBKDRFGFR1RETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |