Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642176 | 0.91 | ERCC1 (0.48) | POLBERCC1ERCC4PYCR1CRHBP | |
| SCHEMBL5643090 | 0.87 | CRHBP (0.47) | POLBERCC1ERCC4PYCR1CRHBP | |
| SCHEMBL5644728 | 0.86 | POLB (0.45) | POLBPYCR1SLC6A2SLC6A4HTT | |
| SCHEMBL5643681 | 0.86 | ERCC1 (0.44) | POLBERCC1ERCC4PYCR1CRHBP | |
| SCHEMBL5644342 | 0.86 | SLC6A2 (0.55) | ERCC1ERCC4PYCR1CRHBPCRHR2 | |
| SCHEMBL5642804 | 0.82 | MEN1 (0.50) | POLBERCC1ERCC4PYCR1CRHBP | |
| SCHEMBL2568818 | 0.81 | HTT (0.49) | ERCC1ERCC4PYCR1HTTKMT2A | |
| SCHEMBL29335165 | 0.81 | HTT (0.47) | POLBERCC1ERCC4PYCR1CRHBP | |
| SCHEMBL29334865 | 0.80 | EPHX2 (0.51) | CRHBPCRHR2HTTALDH1A1 | |
| SCHEMBL9824373 | 0.77 | FSCN1 (0.53) | ERCC1ERCC4PYCR1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |