Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646860 | 0.88 | NSD2 (0.44) | POLBNSD2MEN1KMT2AATM | |
| SCHEMBL5643958 | 0.86 | KMT2A (0.49) | MEN1KMT2AATMSLC6A2SLC6A4 | |
| SCHEMBL5644587 | 0.86 | RIPK1 (0.54) | POLBNSD2MEN1KMT2AATM | |
| SCHEMBL5644680 | 0.86 | POLB (0.47) | POLBMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL5644735 | 0.78 | RIPK1 (0.54) | NSD2MEN1KMT2AATMALDH1A1 | |
| SCHEMBL5642176 | 0.77 | ERCC1 (0.48) | POLBMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL5643090 | 0.74 | CRHBP (0.47) | POLBMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL5643407 | 0.74 | RIPK1 (0.56) | NSD2MEN1KMT2AATMALDH1A1 | |
| SCHEMBL5646227 | 0.73 | RIPK1 (0.54) | NSD2MEN1KMT2AATMALDH1A1 | |
| SCHEMBL5643681 | 0.73 | ERCC1 (0.44) | POLBMEN1KMT2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |