Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647255 | 0.84 | RIPK1 (0.41) | KMT2AMEN1L3MBTL1HTTLMNA | |
| SCHEMBL16427158 | 0.84 | F2 (0.39) | KMT2AMEN1L3MBTL1HTTTHRB | |
| SCHEMBL5645549 | 0.82 | ALDH1A1 (0.42) | KDM4ETAAR1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL5650158 | 0.82 | CYP3A4 (0.42) | KMT2AMEN1L3MBTL1HTTKDM4E | |
| SCHEMBL1799391 | 0.81 | MEN1 (0.46) | KMT2AMEN1L3MBTL1HTTLMNA | |
| SCHEMBL8754809 | 0.81 | LMNA (0.39) | KMT2AMEN1L3MBTL1HTTLMNA | |
| SCHEMBL5648402 | 0.77 | RIPK1 (0.38) | KMT2AMEN1L3MBTL1HTTLMNA | |
| SCHEMBL14674314 | 0.74 | LPAR1 (0.40) | KMT2AMEN1L3MBTL1HTTALDH1A1 | |
| SCHEMBL15328453 | 0.73 | MEN1 (0.50) | KMT2AMEN1L3MBTL1HTTLMNA | |
| SCHEMBL14674236 | 0.71 | ALDH1A1 (0.46) | KMT2AMEN1L3MBTL1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | PLG, F2, PLAT | KMT2A 2105/4885MEN1 1252/4885L3MBTL1 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.