Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460926 | 0.91 | LMNA (0.64) | LMNASMN1; SMN2MAPTRAB9ANPSR1 | |
| SCHEMBL5641667 | 0.86 | GRIN1 (0.67) | LMNASMN1; SMN2MAPTGAAMEN1 | |
| SCHEMBL9710275 | 0.85 | LMNA (0.59) | LMNASMN1; SMN2MAPTGAAMEN1 | |
| SCHEMBL5644846 | 0.84 | LMNA (0.57) | LMNASMN1; SMN2MAPTHDAC1HDAC6 | |
| SCHEMBL2912570 | 0.84 | SMN1; SMN2 (0.82) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5645103 | 0.81 | HPGD (0.62) | LMNASMN1; SMN2MAPTKMT2AHPGD | |
| SCHEMBL4143643 | 0.80 | LMNA (0.60) | LMNASMN1; SMN2MAPTGAAMEN1 | |
| SCHEMBL18669063 | 0.80 | SYK (0.58) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3459833 | 0.80 | GAA (0.55) | LMNAGAAMEN1KMT2AHPGD | |
| SCHEMBL6361747 | 0.79 | LMNA (0.56) | LMNASMN1; SMN2ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |