Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648574 | 0.80 | LMNA (0.75) | LMNAKMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL5644846 | 0.80 | LMNA (0.57) | LMNAMAPTSMN1; SMN2TRPV1 | |
| SCHEMBL9416606 | 0.79 | NPC1 (0.82) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11761142 | 0.79 | NPC1 (0.82) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16562244 | 0.79 | RAB9A (0.74) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL2918147 | 0.78 | NPC1 (0.83) | LMNAKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL6358788 | 0.78 | ALDH1A1 (0.60) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL16685001 | 0.77 | NPC1 (0.83) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4155602 | 0.75 | NPC1 (0.69) | LMNAKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8598019 | 0.75 | NPC1 (0.69) | LMNAKMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069286-A1 | INHIBITORS FOR GLYT-1 | F. Hoffmann-Roche AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008025694-A1 | INHIBITORS FOR GLYT-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |