SCHEMBL5649101

SCHEMBL5649101

COc1ccc2[nH]c(-c3ccc(C(=O)NC4CC(C)(C)NC(C)(C)C4)cc3F)nc2c1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.50
ATM Q13315 1/20 0.50
EZH2 Q15910 5/20 0.47
AMY1A P0DUB6 4/20 0.47
HPGDS O60760 2/20 0.46
GLA P06280 1/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
PKM P14618 1/20 0.45
FLT3 P36888 1/20 0.44
CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5649091 0.93 AMY1A (0.52) L3MBTL1ATMEZH2AMY1AHPGDS
SCHEMBL5651982 0.90 MEN1 (0.53) L3MBTL1ATMEZH2HPGDSGLA
SCHEMBL5652674 0.86 L3MBTL1 (0.52) L3MBTL1ATMEZH2GLAMEN1
SCHEMBL5650746 0.86 ATM (0.47) L3MBTL1ATMEZH2HPGDSGLA
SCHEMBL5648784 0.86 ATM (0.54) L3MBTL1ATMEZH2HPGDSGLA
SCHEMBL5651966 0.86 L3MBTL1 (0.47) L3MBTL1ATMEZH2GLAMEN1
SCHEMBL5651302 0.85 MEN1 (0.53) L3MBTL1EZH2GLAMEN1KMT2A
SCHEMBL5650923 0.84 MEN1 (0.53) L3MBTL1EZH2GLAMEN1KMT2A
SCHEMBL5650914 0.84 MEN1 (0.53) L3MBTL1EZH2GLAMEN1KMT2A
SCHEMBL5651972 0.83 MEN1 (0.53) L3MBTL1ATMEZH2HPGDSGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7220769-B2 Azolylbenzamides and analogues and their use for treating osteoporosis NIKEM RESEARCH S.R.L. (IT) 2007-05-22 US disclosed
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis 3-V BIOSCIENCES, INC. 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis NR0B2, NR0B1, NCOR1 L3MBTL1 1534/4885ATM 2427/4885EZH2 879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.