SCHEMBL565035

SCHEMBL565035

Nc1cccc(Nc2ccc(N)c(O)c2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.60
TDP1 Q9NUW8 3/20 0.60
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
KDM4E B2RXH2 3/20 0.60
GAA P10253 2/20 0.60
LMNA P02545 1/20 0.60
GFER P55789 1/20 0.60
DDX3X O00571 1/20 0.47
RAPGEF4 Q8WZA2 1/20 0.46
ALDH1A1 P00352 5/20 0.44
CYP3A4 P08684 5/20 0.43
ALOX15 P16050 2/20 0.43
RECQL P46063 2/20 0.43
THRB P10828 1/20 0.43
HIF1A Q16665 1/20 0.43
MAPK14 Q16539 2/20 0.43
HSD17B10 Q99714 1/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL565079 0.86 ALOX15 (0.54) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL564726 0.85 CYP3A4 (0.60) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL477516 0.85 ALDH1A1 (0.59) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL564967 0.85 MAPT (0.60) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL564600 0.85 ALDH1A1 (0.54) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL564670 0.82 CYP3A4 (0.52) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL17414842 0.82 MAPT (0.67) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL17508259 0.82 TDP1 (0.56) MAPTTDP1MEN1KMT2AKDM4E
SCHEMBL2127990 0.82 MAPT (0.86) MAPTTDP1MEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL17508329 0.81 MAPT (0.64) MAPTTDP1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO claimed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed
US-8674029-B2 Method of preparing stabilized polymeric systems using polymeric peroxides Sunocs LLC (US) 2014-03-18 US disclosed
US-20120035307-A1 PROCESS FOR MAKING STABLIZED POLYMERIC SYSTEMS WITH NANOSTRUCTURES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20120035315-A1 METHOD OF PREPARING STABLIZED POLYMERIC SYSTEMS USING POLYMERIC PEROXIDES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-7498467-B2 Antioxidant and bisaminophenol derivative IDEMITSU KOSAN CO., LTD. (JP) 2009-03-03 US disclosed
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN CO., LTD. (JP) 2008-07-03 US disclosed
US-20060208227-A1 Antioxidant and bisaminophenol derivative IDEMITSU LOSAN CO., LTD (JP) 2006-09-21 US disclosed
EP-1612254-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN COMPANY LIMITED (JP) 2006-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE CBR1, CBR3, HMOX1 MAPT 3886/4885TDP1 1337/4885MEN1 4479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.