Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 18/20 | 0.48 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047623 | 0.97 | OPRM1 (0.49) | OPRM1OGFRL1OPRL1OPRK1 | |
| SCHEMBL4050098 | 0.77 | OPRM1 (0.48) | OPRM1OGFRL1OPRL1OPRK1 | |
| SCHEMBL1304619 | 0.75 | OPRM1 (0.60) | OPRM1OGFRL1OPRL1OPRK1 | |
| SCHEMBL1303620 | 0.75 | OPRM1 (0.59) | OPRM1OGFRL1OPRL1OPRK1 | |
| Trifluoromethanesulfonic Acid SCHEMBL4049406 | 0.74 | OPRM1 (0.46) | OPRM1OGFRL1OPRL1OPRK1 | |
| Trifluoromethanesulfonic Acid SCHEMBL4057296 | 0.74 | OPRM1 (0.46) | OPRM1OGFRL1OPRL1OPRK1 | |
| SCHEMBL4049796 | 0.72 | OPRM1 (0.56) | OPRM1OGFRL1OPRL1OPRK1 | |
| SCHEMBL4050797 | 0.71 | OPRM1 (0.55) | OPRM1OGFRL1OPRL1OPRK1 | |
| SCHEMBL4046970 | 0.71 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1OPRK1 | |
| Citric Acid SCHEMBL1305034 | 0.69 | OPRM1 (0.48) | OPRM1OGFRL1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288560-B2 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2007-10-30 | — | — | US | disclosed |
| US-20050187281-A1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187281-A1 | Spirocyclic cyclohexane derivatives | PKD2, PKD1, VKORC1 | OPRM1 1427/4885OPRK1 335/4885OGFRL1 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.