Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.62 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877934 | 0.96 | HRH3 (0.68) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL2762024 | 0.94 | HRH3 (0.71) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL2761916 | 0.94 | HRH3 (0.71) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL9034274 | 0.92 | HRH3 (0.69) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL916318 | 0.92 | HRH3 (0.69) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL11027036 | 0.84 | SIGMAR1 (0.60) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL1509554 | 0.84 | LMNA (0.70) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL321095 | 0.82 | SIGMAR1 (0.60) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL6965669 | 0.82 | SIGMAR1 (0.68) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL2234644 | 0.82 | SIGMAR1 (0.63) | SIGMAR1HRH3L3MBTL1MBTD1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213355-A1 | 1H-Imidazo[4,5-C]Quinoline Derivatives in the Treatment of Protein Kinase Dependent Diseases | CAPRARO HANS-GEORG | 2007-09-13 | — | — | US | disclosed |
| EP-1689747-A1 | 1H-IMIDAZO [4,5-C] QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | Novartis AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005054238-A1 | 1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213355-A1 | 1H-Imidazo[4,5-C]Quinoline Derivatives in the Treatment of Protein Kinase Dependent Diseases | ABL1, PRKCA, PRKCQ | SIGMAR1 4023/4885HRH3 1095/4885L3MBTL1 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.