Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437759 | 0.85 | TSHR (0.58) | TSHRALDH1A1HTTCYP3A4TDP1 | |
| Ammonia Solution, Strong SCHEMBL28208001 | 0.83 | TSHR (0.56) | TSHRALDH1A1HTTCYP3A4TDP1 | |
| SCHEMBL7690047 | 0.78 | ALDH1A1 (0.45) | TSHRALDH1A1HTTCYP3A4TDP1 | |
| SCHEMBL29664408 | 0.76 | TSHR (0.48) | TSHRALDH1A1HTTCYP3A4TDP1 | |
| SCHEMBL899149 | 0.76 | TSHR (0.48) | TSHRALDH1A1HTTTDP1L3MBTL1 | |
| SCHEMBL5864975 | 0.76 | TSHR (0.48) | TSHRALDH1A1HTTCYP3A4TDP1 | |
| SCHEMBL31481313 | 0.76 | MAPT (0.51) | TSHRALDH1A1HTTTDP1L3MBTL1 | |
| SCHEMBL11843690 | 0.73 | TSHR (0.45) | TSHRALDH1A1HTTTDP1POLB | |
| SCHEMBL10962494 | 0.73 | TSHR (0.45) | TSHRALDH1A1HTTTDP1POLB | |
| SCHEMBL10517534 | 0.72 | MAPT (0.58) | ALDH1A1HTTCYP3A4TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273863-B1 | Benzophenones as inhibitors of reverse transcriptase | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-25 | — | — | US | disclosed |
| EP-1710238-A1 | Benzophenones as inhibitors of reverse transcriptase | GLAXO GROUP LIMITED (GB) | 2006-10-11 | — | — | EP | disclosed |
| CN-1213038-C | Benzophenones as reverse transcriptase inhibitors | GLAXO GROUP LTD (GB) | 2005-08-03 | — | — | CN | disclosed |
| CN-1636986-A | Benzophenones as inhibitors of reverse transcriptase | GLAXO GROUP LTD (GB) | 2005-07-13 | — | — | CN | disclosed |
| CN-1636985-A | Benzophenones as inhibitors of reverse transcriptase | GLAXO GROUP LTD (GB) | 2005-07-13 | — | — | CN | disclosed |
| CN-1636984-A | Benzophenones as inhibitors of reverse transcriptase | GLAXO GROUP LTD (GB) | 2005-07-13 | — | — | CN | disclosed |
| CN-1391565-A | Benzophenones as reverse transcriptase inhibitors | GLAXO GROUP LTD (GB) | 2003-01-15 | — | — | CN | disclosed |
| EP-1208091-A1 | BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE | GLAXO GROUP LIMITED (GB) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001017982-A1 | BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE | GLAXO GROUP LIMITED (GB) | 2001-03-15 | — | — | WO | disclosed |