Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437759 | 0.85 | TSHR (0.58) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL805900 | 0.85 | ALDH1A1 (0.56) | TSHRALDH1A1HTTCYP19A1HSD17B10 | |
| Ammonia Solution, Strong SCHEMBL28208001 | 0.83 | TSHR (0.56) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL5864975 | 0.76 | TSHR (0.48) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL31481313 | 0.76 | MAPT (0.51) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL5652028 | 0.76 | TSHR (0.48) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL29664408 | 0.76 | TSHR (0.48) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL10962494 | 0.73 | TSHR (0.45) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL11843690 | 0.73 | TSHR (0.45) | TSHRALDH1A1HTTMAPTCYP19A1 | |
| SCHEMBL1797796 | 0.72 | ALDH1A1 (0.49) | TSHRALDH1A1HTTMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391663-B2 | Isoindolinone compounds | MONTE ROSA THERAPEUTICS AG (CH) | 2025-08-19 | — | — | US | disclosed |
| CN-114945571-B | Cyclic compounds and methods of use thereof | 薛定谔公司 | 2025-02-25 | — | — | CN | disclosed |
| US-20240261274-A1 | TREATMENT OF MYC-DRIVEN CANCERS WITH GSPT1 DEGRADERS | MONTE ROSA THERAPEUTICS AG (CH) | 2024-08-08 | — | — | US | disclosed |
| US-20240216355-A1 | PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS | MONTE ROSA THERAPEUTICS AG (CH) | 2024-07-04 | — | — | US | disclosed |
| US-20240083869-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2024-03-14 | — | — | US | disclosed |
| US-11926632-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2024-03-12 | — | — | US | disclosed |
| US-11912682-B2 | Isoindolinone compounds | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| EP-4323349-A1 | ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| US-20240051937-A1 | ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 | MONTE ROSA THERAPEUTICS AG (CH) | 2024-02-15 | — | — | US | disclosed |
| EP-4313047-A1 | PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS | Monte Rosa Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| US-7884112-B2 | Glycogen phosphorylase inhibitor; antidiabetic agents; hypoglycemic agents; hypercholesterolemia; hypotensive agents; antilipemic agents; hypotensive agents; antiischemic agents | BRADLEY STUART EDWARD | 2011-02-08 | — | — | US | disclosed |
| EP-1725555-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID HYDRAZIDES AS INHIBITORS OF GLYCOGEN PHOSPHORYLASE | PROSIDION LTD (GB) | 2010-10-06 | — | — | EP | disclosed |
| US-20080269277-A1 | Pyrrolopyridine-2-Carboxylic Acid Hydrazides | BRADLEY STUART EDWARD | 2008-10-30 | — | — | US | disclosed |
| EP-1725555-A1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID HYDRAZIDES AS INHIBITORS OF GLYCOGEN PHOSPHORYLASE | Prosidion Ltd. (GB) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085245-A9 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID HYDRAZIDES | — | 2006-01-05 | — | — | WO | disclosed |
| WO-2005085245-A1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID HYDRAZIDES | PROSIDION LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |
| US-4786317-A | 4-phenoxy-pyridines having herbicidal activity | CELAMERCK GMBH & CO. KG (DE) | 1988-11-22 | — | — | US | disclosed |
| US-4655824-A | Certain trifluoromethoxy-phenoxy-pyridines having herbicidal activity | CELAMERCK GMBH & CO. KG (DE) | 1987-04-07 | — | — | US | disclosed |
| EP-0086375-B1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE | CELAMERCK GmbH & Co. KG (DE) | 1986-04-09 | — | — | EP | disclosed |
| EP-0086375-A2 | Pyridine derivatives, their preparation and use | CELAMERCK GmbH & Co. KG (DE) | 1983-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12391663-B2 | Isoindolinone compounds | CYP4F2, AOC2, AOC3 | TSHR 1114/4885ALDH1A1 1142/4885HTT 4306/4885 |
| US-20240083869-A1 | ISOINDOLINONE COMPOUNDS | CYP4F2, AOC2, AOC3 | TSHR 1114/4885ALDH1A1 1142/4885HTT 4306/4885 |
| US-20240216355-A1 | PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS | UPF1, NSUN2, RTF2 | TSHR 1410/4885ALDH1A1 4150/4885HTT 868/4885 |
| US-11926632-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, HRAS | TSHR 3762/4885ALDH1A1 2214/4885HTT 2757/4885 |
| US-20240051937-A1 | ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 | GSPT2, GSPT1, NMT2 | TSHR 1013/4885ALDH1A1 2870/4885HTT 3206/4885 |
| US-20080269277-A1 | Pyrrolopyridine-2-Carboxylic Acid Hydrazides | PYGL, PDK1, PYGM | TSHR 3436/4885ALDH1A1 339/4885HTT 1955/4885 |
| US-11912682-B2 | Isoindolinone compounds | CYP4F2, AOC2, AOC3 | TSHR 1114/4885ALDH1A1 1142/4885HTT 4306/4885 |
| US-20240261274-A1 | TREATMENT OF MYC-DRIVEN CANCERS WITH GSPT1 DEGRADERS | MYC, MYCBP, GSPT1 | TSHR 2333/4885ALDH1A1 4276/4885HTT 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.