Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | TYMS | P04818 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | P4HB | P07237 | 2/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | ACR | P10323 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652166 | 0.95 | GSK3B (0.54) | GSK3BTYMSGRM5VNN1IRAK4 | |
| SCHEMBL7650287 | 0.89 | GSK3B (0.59) | GSK3BTYMSGRM5P4HBCLK1 | |
| SCHEMBL19203281 | 0.87 | GSK3B (0.54) | GSK3BTYMSGRM5P4HBALDH1A1 | |
| SCHEMBL30444713 | 0.85 | MRGPRX4 (0.56) | GSK3BGRM5P4HBMRGPRX4 | |
| SCHEMBL6972463 | 0.85 | GSK3B (0.56) | GSK3BTYMSGRM5P4HBCLK1 | |
| SCHEMBL17460156 | 0.85 | GSK3B (0.56) | GSK3BTYMSGRM5P4HBCLK1 | |
| SCHEMBL60040 | 0.85 | MRGPRX4 (0.56) | GSK3BGRM5P4HBMRGPRX4 | |
| Hydrochloric Acid SCHEMBL8958853 | 0.85 | LOXL2 (0.56) | GSK3BTYMSVNN1PRSS1ACR | |
| SCHEMBL7656344 | 0.84 | F2 (0.59) | GSK3BTYMSGRM5CLK1DYRK1A | |
| SCHEMBL31384418 | 0.82 | GSK3B (0.57) | GSK3BTYMSGRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| US-4167407-A | 1-Thiadiazolyl-5-acylimidazolidinones | VELSICOL CHEMICAL CORPORATION (US) | 1979-09-11 | — | — | US | disclosed |
| US-4018787-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1977-04-19 | — | — | US | disclosed |