Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | ABL2 | P42684 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 8/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652401 | 0.83 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC6AURKA | |
| SCHEMBL679036 | 0.80 | PTGS1 (0.52) | HDAC1AURKACHEK2CSF1RRET | |
| SCHEMBL1160893 | 0.76 | AURKA (0.48) | HDAC1AURKAPTGS1WDR5ALOX15 | |
| SCHEMBL5648961 | 0.74 | CYP1A2 (0.54) | HDAC1AURKAPTGS1 | |
| SCHEMBL1160927 | 0.74 | HDAC1 (0.52) | HDAC1AURKACHEK2CSF1RRET | |
| SCHEMBL27489099 | 0.74 | MEN1 (0.52) | AURKACHEK2CSF1RRETFLT4 | |
| SCHEMBL13485802 | 0.74 | LMNA (0.61) | HDAC3HDAC1HDAC2HDAC6AURKA | |
| SCHEMBL5235614 | 0.73 | HCAR3 (0.52) | HDAC3HDAC1HDAC2HDAC6PTGS1 | |
| SCHEMBL5237677 | 0.73 | PTGES (0.46) | HDAC3HDAC1HDAC2HDAC6AURKA | |
| SCHEMBL1417617 | 0.72 | KMT2A (0.49) | AURKACHEK2CSF1RRETFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |