SCHEMBL5652317

SCHEMBL5652317

CCCCCC(C)(C)c1ccc(O)c(-c2ccccc2)c1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 20/20 0.60
CNR2 P34972 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19902034 0.96 CNR1 (0.54) CNR1CNR2
SCHEMBL17758307 0.90 CNR1 (0.47) CNR1CNR2
SCHEMBL9817024 0.89 CNR1 (0.47) CNR1CNR2
SCHEMBL4884009 0.89 CNR1 (0.76) CNR1CNR2
SCHEMBL9817033 0.88 ESR1 (0.55) CNR1CNR2
SCHEMBL7699368 0.88 CNR2 (0.62) CNR1CNR2
SCHEMBL8956568 0.87 CNR1 (0.49) CNR1CNR2
SCHEMBL9817080 0.87 ESR1 (0.58) CNR1CNR2
SCHEMBL9817008 0.86 ESR1 (0.49) CNR1CNR2
SCHEMBL9817147 0.86 ESR1 (0.53) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166659-B2 Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof CIBA SPECIALTY CHEMICALS CORPORATION (US) 2007-01-23 US disclosed
US-7148274-B2 Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-12-12 US disclosed
EP-1337520-B1 SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS CIBA SC HOLDING AG (CH) 2004-12-15 EP disclosed
US-20040192927-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof PASTOR STEPHEN D (US) 2004-09-30 US disclosed
US-20040157966-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof PASTOR STEPHEN D (US) 2004-08-12 US disclosed
US-6774238-B2 REACTING 5-SUBSTITUTED BENZOTRIAZOLE WITH ARYLBORONIC ACID IN PRESENCE OF PALLADIUM CATALYST; DEHALOGENATION; ARYLATION CIBA SPECIALTY CHEMICALS CORPORATION 2004-08-10 US disclosed
US-20040092628-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparatiion thereof PASTOR STEPHEN D (US) 2004-05-13 US disclosed
US-6703510-B2 MORE STABLE AND DURABLE; AUTOMOTIVE COATINGS, CANDLE WAX CIBA SPECIALTY CHEMICALS CORPORATION 2004-03-09 US disclosed
US-20030213164-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof PASTOR STEPHEN D (US) 2003-11-20 US disclosed
US-6649770-B1 Exhibit superior hydrolytic stability, handling and storage stability as well as good resistance to extractability when present in stabilized composition CIBA SPECIALTY CHEMICALS CORPORATION 2003-11-18 US disclosed
EP-1337520-A1 SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS Ciba SC Holding AG (CH) 2003-08-27 EP disclosed
US-6515051-B2 Stability and durability and a low loss rate when incorporated into automotive coatings; soluble in a variety of substrates including thermoplastic polymers and often are colorless CIBA SPECIALTY CHEMICALS CORPORATION 2003-02-04 US disclosed
US-6458872-B1 FOR USE IN AUTOMOTIVE COATINGS, THERMOPLASTIC FORMULATIONS CIBA SPECIALTY CHEMICALS CORPORATION 2002-10-01 US disclosed
US-20020099221-A1 Benzotriazole UV absorbers having enhanced durability RAVICHANDRAN RAMANATHAN (US) 2002-07-25 US disclosed
US-20020065341-A1 Benzotriazole UV absorbers having enhanced durability RAVICHANDRAN RAMANATHAN (US) 2002-05-30 US disclosed
WO-2002042281-A1 SUBSTITUTED 5-ARYL AND 5-HETEROARYL-2-(2-HYDROXYPHENYL)-2H-BENZOTRIAZOLE DERIVATIVES AS UV ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2002-05-30 WO disclosed
US-6262151-B1 FOR AUTOMOTIVE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-17 US disclosed
US-20010007886-A1 Benzotriazole UV absorbers having enhanced durability RAVICHANDRAN RAMANATHAN (US) 2001-07-12 US disclosed
US-6166218-A Benzotriazole UV absorbers having enhanced durability CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-12-26 US disclosed
US-5977219-A Benzotriazole UV absorbers having enhanced durability CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192927-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof EBPL, DDT, AHR CNR1 2333/4885CNR2 1960/4885
US-20030213164-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2H-benzotriazole UV absorbers, compositions stabilized therewith and process for preparation thereof EBPL, DDT, AHR CNR1 2333/4885CNR2 1960/4885
US-20020099221-A1 Benzotriazole UV absorbers having enhanced durability TERT, AHR, ARNT CNR1 2980/4885CNR2 2562/4885
US-20040092628-A1 Substituted 5-aryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, compositions stabilized therewith and process for preparatiion thereof AHR, PAH, CCNL2 CNR1 1751/4885CNR2 1562/4885
US-20020065341-A1 Benzotriazole UV absorbers having enhanced durability TERT, AHR, ARNT CNR1 2980/4885CNR2 2562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.