SCHEMBL5652381

SCHEMBL5652381

Cc1c(Br)cc2nc(-c3ccc(C(=O)NN4CCCCC4)cc3F)[nH]c2c1C

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 14/20 0.36
CNR2 P34972 12/20 0.36
HTT P42858 1/20 0.36
HDAC6 Q9UBN7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5650045 0.92 HTT (0.38) CNR1CNR2HTT
SCHEMBL5654053 0.91 CNR1 (0.37) CNR1CNR2HTT
SCHEMBL5651630 0.87 MEN1 (0.41) HDAC6
SCHEMBL5651564 0.85 HTT (0.41) CNR1HTTHDAC6
SCHEMBL5654014 0.85 HPSE (0.40) CNR1CNR2HTT
SCHEMBL5651507 0.79 FLT3 (0.45)
SCHEMBL5653971 0.78 AMY1A (0.42) CNR1CNR2HDAC6
SCHEMBL5651785 0.77 TSHR (0.52) HTT
SCHEMBL5652478 0.77 HDAC6 (0.48) CNR1HTTHDAC6
SCHEMBL5650995 0.77 PRSS12 (0.47) CNR1CNR2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7220769-B2 Azolylbenzamides and analogues and their use for treating osteoporosis NIKEM RESEARCH S.R.L. (IT) 2007-05-22 US disclosed
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis 3-V BIOSCIENCES, INC. 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis NR0B2, NR0B1, NCOR1 CNR1 68/4885CNR2 129/4885HTT 4354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.