SCHEMBL5652805

SCHEMBL5652805

Cc1cc2[nH]c(-c3ccc(C(=O)NCCCN4CCOCC4)s3)nc2cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
HTR2A P28223 1/20 0.49
ALDH1A1 P00352 3/20 0.48
KDM4E B2RXH2 2/20 0.48
HPGD P15428 2/20 0.48
HSD17B10 Q99714 2/20 0.48
GAA P10253 2/20 0.48
STAT3 P40763 2/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
TP53 P04637 1/20 0.48
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
GLA P06280 1/20 0.45
KLK7 P49862 1/20 0.44
SMYD2 Q9NRG4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5652813 0.97 L3MBTL1 (0.51) MEN1KMT2AL3MBTL1HTR2AALDH1A1
SCHEMBL5651258 0.90 L3MBTL1 (0.51) MEN1KMT2AL3MBTL1ALDH1A1KDM4E
SCHEMBL5651264 0.89 L3MBTL1 (0.51) MEN1KMT2AL3MBTL1ALDH1A1KDM4E
SCHEMBL5650430 0.84 MAPK14 (0.53) ALDH1A1KDM4EHTTSMN1; SMN2
SCHEMBL5652195 0.83 FLT3 (0.45) KDM4EHSD17B10
SCHEMBL5653779 0.83 TNKS2 (0.51) KMT2ALMNASMN1; SMN2
SCHEMBL5651073 0.82 MEN1 (0.51) MEN1KMT2AL3MBTL1HTR2AALDH1A1
SCHEMBL5651069 0.82 MEN1 (0.51) MEN1KMT2AL3MBTL1HTR2AALDH1A1
SCHEMBL5650438 0.81 MAPK14 (0.53) ALDH1A1KDM4EHTTSMN1; SMN2
SCHEMBL5652697 0.81 MET (0.51) L3MBTL1ALDH1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7220769-B2 Azolylbenzamides and analogues and their use for treating osteoporosis NIKEM RESEARCH S.R.L. (IT) 2007-05-22 US disclosed
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis 3-V BIOSCIENCES, INC. 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050038095-A1 Azolylbenzamides and analogues and their use for treating osteoporosis NR0B2, NR0B1, NCOR1 MEN1 3545/4885KMT2A 439/4885L3MBTL1 1534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.