Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 5/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9190330 | 0.85 | TAAR1 (0.64) | ABCB1TAAR1KCNH2BCHESIGMAR1 | |
| SCHEMBL7591220 | 0.84 | HTR1A (0.71) | ABCB1ABCG2HTR1ADRD2KDM4E | |
| SCHEMBL5436452 | 0.82 | ABCB1 (0.49) | ABCB1TAAR1BCHEABCG2HTR1A | |
| SCHEMBL8372624 | 0.81 | ABCB1 (0.47) | ABCB1TAAR1BCHEHTR1AKDM4E | |
| SCHEMBL11419575 | 0.80 | ABCB1 (0.60) | ABCB1KCNH2BCHEABCG2SIGMAR1 | |
| SCHEMBL7335269 | 0.80 | ABCB1 (0.80) | ABCB1TAAR1KCNH2ABCG2HTR1A | |
| SCHEMBL15899172 | 0.79 | HTR1A (0.46) | ABCB1HTR1ADRD2LMNAHTT | |
| SCHEMBL15899170 | 0.79 | HTR1A (0.46) | ABCB1HTR1ADRD2LMNAHTT | |
| SCHEMBL987104 | 0.79 | ABCB1 (0.57) | ABCB1BCHEABCG2TDP1L3MBTL1 | |
| SCHEMBL792023 | 0.77 | TAAR1 (0.64) | ABCB1TAAR1KCNH2HTTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250432-B2 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-31 | — | — | US | disclosed |
| WO-2006126751-A1 | NEW DIARYL-ISOXAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME FOR THE PREVENTION AND THE TREATMENT OF CANCERS | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2006-11-30 | — | — | WO | disclosed |
| US-20050131036-A1 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131036-A1 | Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers | UACA, SQLE, ALDH1A2 | ABCB1 309/4885TAAR1 4788/4885KCNH2 3261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.