Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653143 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4ELMNASMN1; SMN2 | |
| SCHEMBL5654889 | 0.84 | MIF (0.44) | ALDH1A1HPGDKDM4EMAPTMIF | |
| SCHEMBL5654892 | 0.84 | MIF (0.44) | ALDH1A1HPGDKDM4EMAPTMIF | |
| Hydrochloric Acid SCHEMBL5654358 | 0.79 | ITGB3 (0.38) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL5654363 | 0.79 | ITGB3 (0.38) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| SCHEMBL5657092 | 0.78 | MIF (0.39) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| SCHEMBL5657087 | 0.78 | MIF (0.39) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| SCHEMBL5655143 | 0.77 | PDE3B (0.42) | RAB9AMIFHDAC6 | |
| SCHEMBL5655145 | 0.77 | PDE3B (0.42) | RAB9AMIFHDAC6 | |
| SCHEMBL5654137 | 0.76 | MIF (0.39) | ALDH1A1HPGDKDM4EMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281916-A1 | Substituted isoxazolines and their use as antibacterial agents | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | US | disclosed |
| US-7081538-B1 | Substituted isoxazolines and their use as antibacterial agents | ASTRAZENECA AB (SE) | 2006-07-25 | — | — | US | disclosed |
| EP-1242416-B1 | SUBSTITUTED ISOXAZOLINES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2005-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281916-A1 | Substituted isoxazolines and their use as antibacterial agents | CYP2S1, CYP3A7, CYP3A5 | ALDH1A1 3087/4885HPGD 2189/4885KDM4E 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.