Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650973 | 0.81 | CHRNB2 (0.60) | CHRNB2CHRNA4HTR2CHTR2B | |
| SCHEMBL4959088 | 0.76 | CHRNB4 (0.50) | CHRNB2CHRNA4DDB1CRBNMTNR1A | |
| SCHEMBL4406657 | 0.71 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7 | |
| Hydrochloric Acid SCHEMBL4404968 | 0.70 | CHRNB2 (0.96) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL18117805 | 0.68 | MTNR1A (0.50) | CHRNB2CHRNA4DDB1CRBNMTNR1A | |
| SCHEMBL28927762 | 0.66 | HTR2C (0.41) | HTR2CHTR2BDDB1CRBNALDH1A1 | |
| SCHEMBL28927763 | 0.66 | HTR2C (0.41) | HTR2CHTR2BDDB1CRBNALDH1A1 | |
| SCHEMBL21606744 | 0.66 | CHRNB2 (0.51) | CHRNB2CHRNA4HTR2CHTR2BCHRNA7 | |
| SCHEMBL30665167 | 0.66 | CHRNB2 (0.51) | CHRNB2CHRNA4HTR2CHTR2BCHRNA7 | |
| SCHEMBL1197859 | 0.66 | CALCRL (0.43) | CHRNB2CHRNA4HTR2CHTR2BDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066827-A1 | Process for the preparation of aryl fused polycyclic lactams | PFIZER INC. | 2007-03-22 | — | — | US | claimed |
| EP-1587794-A1 | PROCESS FOR THE PREPARATION OF ARYL FUSED POLYCYCLIC LACTAMS | Pfizer Products Inc. (US) | 2005-10-26 | — | — | EP | claimed |
| WO-2004063164-A1 | PROCESS FOR THE PREPARATION OF ARYL FUSED POLYCYCLIC LACTAMS | PFIZER PRODUCTS INC. (US) | 2004-07-29 | — | — | WO | claimed |
| US-20070066827-A1 | Process for the preparation of aryl fused polycyclic lactams | PFIZER INC. | 2007-03-22 | — | — | US | disclosed |
| EP-1587794-A1 | PROCESS FOR THE PREPARATION OF ARYL FUSED POLYCYCLIC LACTAMS | Pfizer Products Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004063164-A1 | PROCESS FOR THE PREPARATION OF ARYL FUSED POLYCYCLIC LACTAMS | PFIZER PRODUCTS INC. (US) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066827-A1 | Process for the preparation of aryl fused polycyclic lactams | PAICS, GRIN2C, FDPS | CHRNB2 2093/4885CHRNA4 1122/4885HTR2C 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.