Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 4/20 | 0.40 |
| ▸ | SMO | Q99835 | 4/20 | 0.40 |
| ▸ | ERG | P11308 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654274 | 0.89 | SMO (0.39) | HTTL3MBTL1ALDH1A1MMP8MMP3 | |
| SCHEMBL14366931 | 0.87 | MMP8 (0.52) | ALDH1A1MMP8MMP3SMOMMP1 | |
| SCHEMBL5652538 | 0.87 | SMO (0.45) | HTTL3MBTL1MMP3SMOCNR1 | |
| SCHEMBL5654387 | 0.87 | SMO (0.41) | HTTL3MBTL1ALDH1A1MMP8MMP3 | |
| SCHEMBL5654206 | 0.86 | FASN (0.41) | ALDH1A1MMP8MMP3SMOTACR3 | |
| SCHEMBL5653667 | 0.85 | GRM5 (0.46) | GRM5HTTL3MBTL1ALDH1A1MMP8 | |
| SCHEMBL5652388 | 0.85 | SMO (0.50) | HTTL3MBTL1SMOGHSRMMP13 | |
| SCHEMBL5653521 | 0.84 | SLC6A7 (0.47) | ALDH1A1MMP8MMP3SMOMMP1 | |
| SCHEMBL5652861 | 0.84 | SMO (0.46) | MMP3SMOMMP1MMP7GHSR | |
| SCHEMBL5653713 | 0.83 | SMO (0.40) | HTTL3MBTL1MMP3SMOMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259879-A1 | Piperazine and piperidine biaryl derivatives | TRIMERIS, INC. | 2007-11-08 | — | — | US | disclosed |
| US-20070259879-A1 | Piperazine and piperidine biaryl derivatives | TRIMERIS, INC. | 2007-11-08 | — | — | US | disclosed |
| US-20070259879-A1 | Piperazine and piperidine biaryl derivatives | TRIMERIS, INC. | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259879-A1 | Piperazine and piperidine biaryl derivatives | CYP3A5, CYP3A43, CCR5 | GRM5 749/4885HTT 3642/4885L3MBTL1 4497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.