Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950842 | 0.84 | TSHR (0.44) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL14541169 | 0.84 | TSHR (0.44) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL8950839 | 0.84 | TSHR (0.44) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL5889904 | 0.82 | TRPA1 (0.41) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL26989268 | 0.82 | TSHR (0.46) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL26988083 | 0.82 | TSHR (0.46) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL26987985 | 0.82 | TSHR (0.46) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL26988540 | 0.82 | TSHR (0.46) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL428101 | 0.82 | TSHR (0.46) | TRPA1HPGDSIGMAR1KMT2AMEN1 | |
| SCHEMBL29929713 | 0.82 | TRPA1 (0.51) | TRPA1HPGDSIGMAR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235082-A1 | Long-chain, straight-chain 2-amino-3-hydroxyalkanes | RINEHART KENNETH L | 2006-10-19 | — | — | US | disclosed |
| US-7109244-B2 | Compositions and methods comprising long-chain, straight-chain 2-amino-3-hydroxyalkanes | RINEHART KENNETH L | 2006-09-19 | — | — | US | disclosed |
| US-20060183806-A9 | COMPOSITIONS AND METHODS COMPRISING LONG-CHAIN, STRAIGHT-CHAIN 2-AMINO-3- HYDROXYALKANES | RINEHART KENNETH L | 2006-08-17 | — | — | US | disclosed |
| US-RE38793-E1 | Spisulosine compounds | RINEHART KENNETH L | 2005-09-06 | — | — | US | disclosed |
| EP-1069894-B1 | SPISULOSINE COMPOUNDS HAVING ANTITUMOUR ACTIVITY | UNIV ILLINOIS (US) | 2005-08-31 | — | — | EP | disclosed |
| US-6800661-B1 | Spisulosine compounds | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2004-10-05 | — | — | US | disclosed |
| US-20040147615-A1 | Spisulosine compounds | RINEHART KENNETH L (US) | 2004-07-29 | — | — | US | disclosed |
| EP-1069894-A1 | SPISULOSINE COMPOUNDS HAVING ANTITUMOUR ACTIVITY | The Board of Trustees for the University of Illinois (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6107520-A | SHOW UNIQUE CYTOTOXICITY AGAINST MURINE LYMPHOCYTIC LEUKEMIA CELLS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999052521-A1 | SPISULOSINE COMPOUNDS HAVING ANTITUMOUR ACTIVITY | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235082-A1 | Long-chain, straight-chain 2-amino-3-hydroxyalkanes | SLC3A2, HACL2, CLSPN | TRPA1 489/4885HPGD 1344/4885SIGMAR1 309/4885 |
| US-20040147615-A1 | Spisulosine compounds | CLSPN, SPIN3, OAT | TRPA1 1152/4885HPGD 2908/4885SIGMAR1 616/4885 |
| US-20060183806-A9 | COMPOSITIONS AND METHODS COMPRISING LONG-CHAIN, STRAIGHT-CHAIN 2-AMINO-3- HYDROXYALKANES | NEFM, OAT, POLM | TRPA1 2074/4885HPGD 1239/4885SIGMAR1 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.