Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.57 |
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | OPA1 | O60313 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658117 | 0.92 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CNAMPTHDAC1 | |
| SCHEMBL5656488 | 0.91 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CNAMPTHDAC1 | |
| SCHEMBL5659076 | 0.91 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CNAMPTHDAC1 | |
| SCHEMBL5658814 | 0.89 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CNAMPTHDAC1 | |
| SCHEMBL5656482 | 0.88 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CNAMPTHDAC1 | |
| SCHEMBL5659486 | 0.87 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CHDAC1KDM1A | |
| SCHEMBL5659450 | 0.87 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CHDAC1ALDH1A1 | |
| SCHEMBL5655917 | 0.87 | NAMPT (0.59) | NAMPTHDAC1KDM1AALDH1A1MAPT | |
| SCHEMBL5657259 | 0.87 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CNAMPTHDAC1 | |
| SCHEMBL5657361 | 0.86 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CHDAC1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-6998414-B2 | Substituted arylamides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2006-02-14 | — | — | US | disclosed |
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | INSR, INSRR, GIPR | ADRA2A 90/4885ADRA2B 82/4885ADRA2C 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.