Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.64 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9861324 | 0.76 | ALOX5 (0.63) | ALOX5PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL8684158 | 0.74 | CYP3A4 (0.57) | ALOX5PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL16272594 | 0.74 | ALOX5 (1.00) | ALOX5PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL4916303 | 0.72 | ALDH1A1 (0.44) | ALOX5ERN1PTGES | |
| SCHEMBL4110681 | 0.71 | KDM4E (0.57) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL28344754 | 0.71 | CYP3A4 (0.53) | ALOX5PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL30949367 | 0.70 | ALDH1A1 (0.67) | ALOX5ERN1PTGES | |
| SCHEMBL599396 | 0.70 | ALDH1A1 (0.67) | ALOX5ERN1PTGES | |
| SCHEMBL20168410 | 0.70 | KCNJ1 (0.44) | ALOX5PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL30751840 | 0.70 | KCNJ1 (0.44) | ALOX5PDE1APDE1BPDE3BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166631-B2 | Benzo[f]isoindole derivatives with affinity to the EP4 receptor | GLAXO GROUP LIMITED (GB) | 2007-01-23 | — | — | US | disclosed |