Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 12/20 | 0.76 |
| ▸ | CXCR1 | P25024 | 11/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5661096 | 0.94 | CXCR2 (0.67) | CXCR2CXCR1NPC1RAB9AP4HTM | |
| SCHEMBL5657684 | 0.89 | CXCR1 (0.61) | CXCR2CXCR1KMT2AMEN1LMNA | |
| SCHEMBL5658045 | 0.87 | CXCR2 (0.59) | CXCR2CXCR1KMT2AMEN1LMNA | |
| SCHEMBL5845511 | 0.86 | CXCR2 (1.00) | CXCR2CXCR1KMT2AMEN1LMNA | |
| SCHEMBL5658884 | 0.85 | KMT2A (0.57) | CXCR2CXCR1KMT2AMEN1LMNA | |
| SCHEMBL5660902 | 0.85 | CXCR1 (0.56) | CXCR2CXCR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5660485 | 0.84 | CXCR2 (0.77) | CXCR2CXCR1KMT2AMEN1LMNA | |
| SCHEMBL5658349 | 0.84 | CXCR2 (0.73) | CXCR2CXCR1NPC1RAB9AP4HTM | |
| SCHEMBL5656328 | 0.84 | P4HTM (0.57) | CXCR2CXCR1NPC1RAB9AP4HTM | |
| SCHEMBL5658493 | 0.82 | CXCR2 (0.62) | CXCR2CXCR1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | claimed |
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |