Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5656474 | 0.85 | HTR1A (0.47) | KCNH2HTR1A | |
| SCHEMBL14573158 | 0.84 | SLC2A1 (0.43) | KCNH2 | |
| SCHEMBL5765149 | 0.84 | SLC2A1 (0.43) | KCNH2 | |
| SCHEMBL5659991 | 0.84 | SLC2A1 (0.43) | KCNH2 | |
| Hydrochloric Acid SCHEMBL5655525 | 0.84 | SLC2A1 (0.42) | KCNH2 | |
| SCHEMBL14573142 | 0.83 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5764669 | 0.82 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL5746391 | 0.81 | KCNH2 (0.44) | KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL5748231 | 0.81 | KCNH2 (0.43) | KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL5777425 | 0.79 | KCNH2 (0.40) | KCNH2HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186730-B2 | Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-03-06 | — | — | US | claimed |
| EP-1392686-B1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2006-10-18 | — | — | EP | claimed |
| US-7186730-B2 | Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-03-06 | — | — | US | disclosed |
| EP-1392686-B1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2006-10-18 | — | — | EP | disclosed |