Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | AGXT | P21549 | 2/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866909 | 0.80 | TP53 (0.44) | TSHRALDH1A1TAAR1ABCC4LMNA | |
| SCHEMBL1775203 | 0.80 | TSHR (0.44) | TSHRTAAR1TDP1ABCC4LMNA | |
| SCHEMBL27351758 | 0.80 | TAAR1 (0.54) | TAAR1IDO1AGXT | |
| SCHEMBL5010976 | 0.77 | HSD11B1 (0.36) | ALDH1A1TAAR1RAB9A | |
| SCHEMBL5783938 | 0.76 | CYP3A4 (0.35) | TSHRALDH1A1TAAR1TDP1GAA | |
| SCHEMBL16143237 | 0.73 | TAAR1 (0.38) | ALDH1A1TAAR1LMNAHTT | |
| SCHEMBL28033901 | 0.72 | ALDH1A1 (0.48) | ALDH1A1TDP1RAB9A | |
| SCHEMBL1775198 | 0.72 | TRPA1 (0.44) | TSHRALDH1A1TRPA1CES2CES1 | |
| SCHEMBL2448169 | 0.72 | ALDH1A1 (0.45) | TSHRALDH1A1TAAR1TDP1ABCC4 | |
| SCHEMBL2958548 | 0.72 | ALDH1A1 (0.45) | TSHRALDH1A1TAAR1TDP1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142638-A1 | Ornithine derivatives as prostaglandin e2 agonists or antagonists | ASTELLAS PHARMA INC. (JP) | 2007-06-21 | — | — | US | disclosed |
| CN-1056140-C | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 2000-09-06 | — | — | CN | disclosed |
| CN-1119861-A | 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders | SEARLE & CO (US) | 1996-04-03 | — | — | CN | disclosed |
| CN-1095374-A | Biphenyl derivatives, their preparation and they are in the application for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1994-11-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142638-A1 | Ornithine derivatives as prostaglandin e2 agonists or antagonists | PTGER4, OXER1, RXFP4 | TSHR 380/4885ALDH1A1 1570/4885TRPA1 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.