Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20345418 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4165967 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL5654162 | 0.78 | MAPT (0.46) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Bromide SCHEMBL4880840 | 0.77 | CYP3A4 (0.41) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL16828801 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL31309742 | 0.73 | MAPT (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4663631 | 0.72 | KDM4E (0.42) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL18744225 | 0.72 | ATAD2 (0.37) | KDM4EALDH1A1MAPTGAAATAD2 | |
| SCHEMBL16829238 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL20160086 | 0.69 | ATAD2 (0.36) | ATAD2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167427-A1 | 1,2,4-Triazolo[4,3-a]pyridines useful in the treatment of gastrointestinal disorders | ALTANA PHARMA AG (DE) | 2007-07-19 | — | — | US | disclosed |
| EP-1718646-A1 | 1,2,4-TRIAZOLO[4,3-A]PYRIDINES USEFUL IN THE TREATMENT OF GASTROINTESTINAL DISORDERS | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077947-A1 | 1,2,4-TRIAZOLO[4,3-A]PYRIDINES USEFUL IN THE TREATMENT OF GASTROINTESTINAL DISORDERS | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167427-A1 | 1,2,4-Triazolo[4,3-a]pyridines useful in the treatment of gastrointestinal disorders | GIPR, SLC10A2, GRPR | KDM4E 2708/4885ALDH1A1 782/4885MAPT 4217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.