SCHEMBL5657009

SCHEMBL5657009

[CH2]c1nccc(OC)c1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.43
MAPT P10636 2/20 0.43
MAPK1 P28482 2/20 0.43
TP53 P04637 2/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
CYP3A4 P08684 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
HSD17B10 Q99714 1/20 0.43
NPC1 O15118 2/20 0.39
GAA P10253 2/20 0.39
RAB9A P51151 1/20 0.39
ERN1 O75460 3/20 0.36
TLR2 O60603 1/20 0.36
TLR1 Q15399 1/20 0.36
TLR6 Q9Y2C9 1/20 0.36
SMPD3 Q9NY59 2/20 0.36
CA1 P00915 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7118342 0.77 MAPK1 (0.45) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL1650165 0.77 SMN1; SMN2 (0.38) KDM4EMAPTTP53ALDH1A1LMNA
SCHEMBL4773364 0.77 DYRK1A (0.36) ALDH1A1GAACA1CA2
SCHEMBL8198856 0.77 KDM4E (0.45) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL24122438 0.75 MAPT (0.44) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL15469493 0.75 MAPT (0.43) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL30032251 0.75 NOS3 (0.44) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL4704137 0.75 NOS3 (0.44) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL28861826 0.75 KDM4E (0.43) KDM4EMAPTMAPK1TP53ALDH1A1
SCHEMBL16921629 0.72 ALOX5 (0.41) KDM4EMAPTMAPK1TP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023056089-A1 IMMUNOLOGICAL ADJUVANT FORMULATIONS COMPRISING TLR4 AGONIST E6020 EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-04-06 WO disclosed
WO-2015051079-A2 PHOSPHOHISTIDINE MIMETICS AND ANTIBODIES TO SAME THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2015-04-09 WO disclosed
WO-2014200757-A1 PROTECTED SCALE INHIBITORS AND METHODS RELATING THERETO HALLIBURTON ENERGY SERVICES, INC. (US) 2014-12-18 WO disclosed
US-7250389-B1 Antifungal compound and process for producing the same MEIJI SEIKA KAISHA, LTD. (JP) 2007-07-31 US disclosed
EP-1054011-B1 NOVEL ANTIFUNGAL COMPOUNDS AND PROCESS FOR PRODUCING THE SAME MEIJI SEIKA KAISHA (JP) 2006-09-13 EP disclosed
EP-1263773-A4 OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE ACTIVE MOTIF (US) 2005-08-31 EP disclosed
EP-1481085-A2 OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION Active Motif (US) 2004-12-01 EP disclosed
WO-2003068798-A2 OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION ACTIVE MOTIF (US) 2003-08-21 WO disclosed
EP-1263773-A1 OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE Active Motif (US) 2002-12-11 EP disclosed
WO-2001068673-A1 OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE ACTIVE MOTIF (US) 2001-09-20 WO disclosed
EP-1054011-A1 NOVEL ANTIFUNGAL COMPOUNDS AND PROCESS FOR PRODUCING THE SAME MEIJI SEIKA KAISHA LTD. (JP) 2000-11-22 EP disclosed