Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29488781 | 0.89 | — | — | |
| SCHEMBL11837 | 0.89 | — | — | |
| Formaldehyde SCHEMBL27341516 | 0.86 | ACHE (0.83) | ACHETSHRALDH1A1CES2CES1 | |
| SCHEMBL28557764 | 0.86 | ACHE (0.83) | ACHETSHRALDH1A1CES2CES1 | |
| Hydrochloric Acid SCHEMBL28105763 | 0.86 | ACHE (0.94) | ACHETSHRCYP1A2ALDH1A1GAA | |
| SCHEMBL29176814 | 0.86 | — | — | |
| Fluoride SCHEMBL28142665 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL29088489 | 0.86 | ACHE (0.94) | ACHETSHRCYP1A2ALDH1A1GAA | |
| Fluoride SCHEMBL21816907 | 0.86 | ACHE (0.94) | ACHETSHRCYP1A2ALDH1A1GAA | |
| Iodide SCHEMBL27592623 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226950-B2 | Sodium channel modulators | THERAVANCE, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-20060276467-A1 | An aromatic-oxy-alkyleneamine derivative, useful for treating neuropathic pain | THERAVANCE BIOPHARMA R&D IP, LLC | 2006-12-07 | — | — | US | disclosed |
| US-7132422-B2 | Sodium channel modulators | THERAVANCE, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-20050130966-A1 | Sodium channel modulators | THERAVANCE BIOPHARMA R&D IP, LLC | 2005-06-16 | — | — | US | disclosed |
| US-6872741-B2 | Sodium channel modulators | THERAVANCE, INC. (US) | 2005-03-29 | — | — | US | disclosed |
| US-20040063760-A1 | Sodium channel modulatiors | THERAVANCE BIOPHARMA R&D IP, LLC | 2004-04-01 | — | — | US | disclosed |
| US-6646012-B2 | Central nervous system analgesic; hypotensive agents; antiarrhythmia agents; antidiabetic agents | THERAVANCE, INC. | 2003-11-11 | — | — | US | disclosed |
| US-20030065013-A1 | Sodium channel modulators | THERAVANCE BIOPHARMA R&D IP, LLC | 2003-04-03 | — | — | US | disclosed |
| WO-2002057215-A2 | SODIUM CHANNEL MODULATORS | THERAVANCE, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130966-A1 | Sodium channel modulators | SCN10A, SCN5A, SCN1A | ACHE 491/4885TSHR 4227/4885CYP1A2 4517/4885 |
| US-20060276467-A1 | An aromatic-oxy-alkyleneamine derivative, useful for treating neuropathic pain | TRPV1, TRPA1, OPRL1 | ACHE 367/4885TSHR 4384/4885CYP1A2 3434/4885 |
| US-20040063760-A1 | Sodium channel modulatiors | SCN1A, SCN2A, SCN1B | ACHE 420/4885TSHR 4757/4885CYP1A2 4724/4885 |
| US-20030065013-A1 | Sodium channel modulators | SCN10A, SCN5A, SCN1A | ACHE 491/4885TSHR 4227/4885CYP1A2 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.