Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10262248 | 0.82 | ALDH1A1 (0.53) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL824982 | 0.81 | TDP1 (0.55) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5658295 | 0.73 | PARP1 (0.44) | TDP1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11264007 | 0.73 | ALDH1A1 (0.44) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2191003 | 0.73 | TDP1 (0.52) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL113118 | 0.73 | TXNRD1 (0.41) | TDP1ALDH1A1NCOA1NCOA3GAA | |
| SCHEMBL26059158 | 0.71 | TDP1 (0.69) | TDP1ALDH1A1SMN1; SMN2POLBFBP1 | |
| SCHEMBL2379102 | 0.70 | TDP1 (0.62) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15170251 | 0.70 | ALDH1A1 (0.51) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1351402 | 0.69 | ALDH1A1 (0.55) | TDP1ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | TDP1 4108/4885ALDH1A1 1267/4885SMN1; SMN2 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.